We previously developed Windows-based Biochemical Engineering System analyzing Tool-KIT (WinBEST-KIT), a biochemical reaction simulator for analyzing large-scale and complicated biochemical reaction networks. One particularly notable feature is the ability for users to define original mathematical equations for representing unknown kinetic mechanisms and customize them as GUI components for representing reaction steps. Many simulators support System Biology Markup Language SBML; however, since the definition of the algebraic equations (AssignmentRule) and the events are made through an interface that is distinct from the definition of the reaction steps, there are tough works to define them. Accordingly, we have developed a new version of WinBEST-KIT that allows users to define the algebraic equations and the events through the same interface as those used in the definition of the reaction steps and customize them as GUI components appearing in the symbol selection area. The customized algebraic equations and events can thus be visually arranged at any time and any place. It also allows users to easily understand the roles of the algebraic equations and the events. We have also implemented other useful features, including importing/exporting of SBML format files, exporting to MATLAB, and merging the existing models into the model currently being created. The current version of WinBEST-KIT is freely available at http://winbest-kit.org/ .

中文翻译：

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WinBEST-KIT：生化反应模拟器，可以定义和自定义代数方程和事件作为 GUI 组件

我们之前开发了基于 Windows 的生化工程系统分析工具包 (WinBEST-KIT)，这是一种用于分析大规模复杂生化反应网络的生化反应模拟器。一个特别值得注意的功能是用户能够定义原始数学方程来表示未知的动力学机制，并将它们定制为 GUI 组件来表示反应步骤。许多模拟器支持系统生物学标记语言SBML；但是，由于代数方程 (AssignmentRule) 和事件的定义是通过与反应步骤定义不同的接口进行的，因此定义它们的工作很艰巨。因此，我们开发了新版本的 WinBEST-KIT，它允许用户通过与定义反应步骤相同的界面定义代数方程和事件，并将它们自定义为出现在符号选择区域中的 GUI 组件。因此，定制的代数方程和事件可以在任何时间和任何地点进行可视化排列。它还允许用户轻松理解代数方程和事件的作用。我们还实现了其他有用的功能，包括导入/导出 SBML 格式文件、导出到 MATLAB 以及将现有模型合并到当前正在创建的模型中。当前版本的 WinBEST-KIT 可在 http://winbest-kit.org/ 免费获得。