The hippocampus is particularly involved in cognitive processes and is a key regulator of stress responses and emotions. Therefore, the role of adult-born neurons in this region has become a crucial field of research in order to understand mood and stress disorders, such as major depression. Many studies have characterized the role of these neurons in cognition, mood regulation and antidepressant actions. Nevertheless, the precise mechanisms underpinning these antidepressant effects remain unclear. In this review, we first discuss the effects of stress and antidepressant treatments on adult-born neurons, and subsequently, the role and mechanisms of neurogenesis in antidepressant action. Some studies have shown that adult-born neurons could affect overall hippocampal activity, thus normalizing the latter which could restore neuronal pathways underlying antidepressant effects.

中文翻译：

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成人海马神经发生和抗抑郁作用。

海马特别参与认知过程，并且是压力反应和情绪的关键调节器。因此，成人出生的神经元在该区域的作用已成为研究情绪和压力障碍（例如严重抑郁症）的重要研究领域。许多研究已经表征了这些神经元在认知，情绪调节和抗抑郁作用中的作用。然而，尚不清楚这些抗抑郁作用的确切机制。在这篇综述中，我们首先讨论了压力和抗抑郁治疗对成年出生的神经元的影响，随后讨论了神经发生在抗抑郁作用中的作用和机制。一些研究表明，成年出生的神经元可能会影响整个海马活动，