We investigated the effects of α-lipoic acid (AL) and α-tocopherol (AT) on renal histopathology in a streptozotocin (STZ) induced diabetic rat model. Adult male rats were divided into six groups: group 1, saline only; group 2, AL only; group 3, AT only; group 4, STZ only; group 5, STZ + AL; group 6 STZ + AT. Experimental diabetes was induced by STZ. AL and AT were administered for 15 days. Kidney sections were examined using a light microscope after hematoxylin and eosin (H & E), periodic acid-Schiff (PAS) and caspase-3 staining. Histological damage to glomeruli, tubule epithelial cells and basement membrane was observed in group 4. Administration of AT and AL reduced renal injury in the diabetic rats. Group 5 exhibited a greater curative effect on diabetic rats than group 6. AT and AL may be useful for preventing diabetic renal damage.

中文翻译：

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对实验性糖尿病大鼠模型中α-硫辛酸和α-生育酚的肾脏保护作用的光学显微镜研究。

我们研究了链脲佐菌素（STZ）诱导的糖尿病大鼠模型中α-硫辛酸（AL）和α-生育酚（AT）对肾脏组织病理学的影响。成年雄性大鼠分为六组：第一组，仅加生理盐水；第二组，仅加生理盐水。第2组，仅限AL；第3组，仅限AT；组4，仅STZ；第5组，STZ + AL；6组STZ + AT。实验性糖尿病是由STZ诱发的。AL和AT给药15天。在苏木精和曙红（H＆E），高碘酸席夫（PAS）和caspase-3染色后，使用光学显微镜检查肾脏切片。在第4组中观察到对肾小球，肾小管上皮细胞和基底膜的组织学损害。AT和AL的施用减轻了糖尿病大鼠的肾损伤。与第6组相比，第5组对糖尿病大鼠的治疗效果更好。AT和AL可用于预防糖尿病肾损害。