BACKGROUND Previous studies have reported an association between hyperlipidemia and pancreatitis in dogs, but details of this association remain poorly defined. HYPOTHESIS/OBJECTIVES To compare serum triglyceride and cholesterol concentrations and lipoprotein profiles between dogs with naturally occurring pancreatitis and healthy dogs. ANIMALS Seventeen dogs with a clinical diagnosis of pancreatitis (Group 1) and 53 healthy control dogs (Group 2). METHODS Prospective case-control study. RESULTS In Group 1, 3/17 dogs (18%) had hypertriglyceridemia whereas in Group 2, 4/53 dogs (7.5%) had hypertriglyceridemia (odds ratio [OR], 2.63; 95% confidence interval [CI], 0.52-13.14; P = .35). A significant difference was found in serum triglyceride concentrations between Group 1 (median, 67 mg/dL) and Group 2 (median, 54 mg/dL; P = .002). In Group 1, 4/17 dogs (24%) had hypercholesterolemia, whereas 1/53 (1.9%) dogs in Group 2 had hypercholesterolemia (OR, 16; 95% CI, 1.64-155.5; P = .01). No significant difference was found in serum cholesterol concentrations between Group 1 (median, 209 mg/dL) and Group 2 (median, 227 mg/dL; P = .56). Lipoprotein profiles were significantly different between Group 1 and Group 2 dogs (Eigenvalues, 0.6719; R2 = 1.0; P = .001). CONCLUSIONS AND CLINICAL IMPORTANCE Most dogs with pancreatitis (>70%) had serum triglyceride and cholesterol concentrations within reference intervals. In the small percentage of dogs that had hypertriglyceridemia, hypercholesterolemia, or both, increases were mild. Important differences were identified in lipoprotein profiles between dogs with pancreatitis and healthy control dogs. Dogs with pancreatitis had higher low-density lipoprotein fractions and lower triglyceride-rich lipoprotein and high-density lipoprotein fractions than healthy dogs.

中文翻译：

---

患有天然胰腺炎的犬和健康对照犬的血清甘油三酸酯和胆固醇浓度以及脂蛋白谱。

背景技术先前的研究已经报道了狗中高脂血症和胰腺炎之间的关联，但是这种关联的细节仍然不清楚。假设/目的比较自然发生胰腺炎的狗和健康狗的血清甘油三酸酯和胆固醇浓度以及脂蛋白谱。动物17例临床诊断为胰腺炎的犬（第1组）和53例健康对照犬（第2组）。方法前瞻性病例对照研究。结果在第1组中，3/17的狗（18％）患有高甘油三酸酯血症，而在第2组中，4/53的狗（7.5％）患有高甘油三酸酯血症（赔率[OR]为2.63； 95％置信区间[CI]为0.52-13.14 ； P = 0.35）。发现第一组（中位数为67 mg / dL）和第二组（中位数为54 mg / dL； P = 0.002）之间的血清甘油三酯浓度存在显着差异。在第1组中 第2组中有4/17只狗（24％）患有高胆固醇血症，而第2组中有1/53（1.9％）的狗患有高胆固醇血症（OR，16； 95％CI，1.64-155.5； P = 0.01）。第一组（中位数为209 mg / dL）与第二组（中位数为227 mg / dL； P = 0.56）之间的血清胆固醇浓度无显着差异。脂蛋白谱在第1组和第2组犬之间显着不同（特征值0.6719； R2 = 1.0； P = 0.001）。结论和临床意义大多数患有胰腺炎的狗（> 70％）的血清甘油三酯和胆固醇浓度均在参考区间内。在患有高甘油三酸酯血症，高胆固醇血症或两者的狗中，只有一小部分的增加是轻微的。在患有胰腺炎的犬和健康对照犬之间的脂蛋白谱中鉴定出重要差异。