Abstract

By HPLC-MSⁿ and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]⁺ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro.

中文翻译：

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用HPLC-MSn和HRMS快速鉴定和鉴定Dregea sinensis中聚氧戊二烯苷的结构特征。

摘要

通过HPLC-MS ⁿ和HRMS分析，从Dregea sinensis Hemsl迅速推断出52种聚氧孕烯糖苷的结构，这是基于它们的钠阳离子化分子[M + Na] ⁺和C3上的糖链和糖基化产生的主要诊断离子。 C11和C12上取代基的中性丢失。化合物1和7在体外显着抑制LPS刺激的脾细胞增殖。