The survival and development of a semi-allogeneic fetus during pregnancy require the involvement of a series of cytokines and immune cells. Chemokines are a type of special cytokine those were originally described as having a role in leukocyte trafficking. CXC chemokine ligand (CXCL) 16 is a member of the chemokine family, and CXC chemokine receptor (CXCR) 6 is its sole receptor. Emerging evidence has shown that CXCL16/CXCR6 is expressed at the maternal-fetal interface, by cell types that include trophoblast cells, decidual stroma cells, and decidual immune cells (eg, monocytes, γδT cells, and natural killer T (NKT) cells). The regulation of expression of CXCL16 is quite complex, and this process involves a multitude of factors. CXCL16 exerts a critical role in the establishment of a successful pregnancy through a series of molecular interactions at the maternal-fetal interface. However, an abnormal expression of CXCL16 is associated with certain pathological states associated with pregnancy, including recurrent miscarriage, pre-eclampsia, and gestational diabetes mellitus (GDM). In the present review, the expression and pleiotropic roles of CXCL16 under conditions of physiological and pathological pregnancy are systematically discussed.

中文翻译：

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CXC趋化因子配体16在生理和病理妊娠中的作用。

怀孕期间半同种异体胎儿的生存和发育需要一系列细胞因子和免疫细胞的参与。趋化因子是一种特殊的细胞因子，最初被描述为在白细胞运输中起作用。CXC趋化因子配体（CXCL）16是趋化因子家族的成员，而CXC趋化因子受体（CXCR）6是其唯一受体。新兴证据表明，CXCL16 / CXCR6在母胎界面表达，其细胞类型包括滋养层细胞，蜕膜基质细胞和蜕膜免疫细胞（例如单核细胞，γδT细胞和自然杀伤性T（NKT）细胞） 。CXCL16的表达调控非常复杂，并且该过程涉及多种因素。CXCL16通过母婴界面的一系列分子相互作用，在成功妊娠的建立中起着至关重要的作用。但是，CXCL16的异常表达与某些与妊娠相关的病理状态有关，包括反复流产，先兆子痫和妊娠糖尿病（GDM）。在这篇综述中，系统地讨论了CXCL16在生理和病理妊娠条件下的表达和多效性作用。