Background: A complex set of neurotrophic growth factors participates in neuroplasticity in the aging brain. Platelets are a copious source of growth factors, most of which display also the neurotropic activity. On this basis, we investigated behavioral and cognitive consequences of the administration of intravenous allogeneic platelet-rich plasma (PRP) in senescent mice.Methods: The animals (16-18 months old) were injected with either physiological saline or PRP which was acquired from age-matched counterparts and subjected to a battery of tests comprised of open-field, elevated-plus maze, tail suspension, and Morris water maze test.Results: We found that PRP treatment increases locomotion and improves learning and memory in elderly mice. Importantly, the PRP-treated animals did not exhibit any anxiety- or depression-like behaviors.Conclusion: The present study is the first to demonstrate that allogeneic PRP possesses beneficial effects against cognitive aging and it signifies that PRP may be used as a novel self-sourced treatment in age-related cognitive decline.

中文翻译：

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富含血小板的血浆（PRP）是老年小鼠潜在的自体认知增强剂。

背景：一组复杂的神经营养生长因子参与衰老大脑的神经可塑性。血小板是多种生长因子的来源，其中大多数还表现出神经活性。在此基础上，我们研究了在衰老小鼠中施用静脉内同种异体富血小板血浆（PRP）的行为和认知后果。方法：向这些动物（16-18个月大）注射生理盐水或从与年龄匹配的同龄人进行了一系列测试，包括旷场，高架迷宫，尾部悬架和莫里斯水迷宫测试。结果：我们发现PRP处理可提高运动能力并改善老年小鼠的学习和记忆能力。重要的是，经PRP治疗的动物没有表现出任何焦虑或抑郁样行为。