Parkinson's disease (PD) is another major neurodegenerative disorder following Alzheimer's disease, which not only seriously reduces the survival in patients, affecting patient's quality of life, but also imposes a tremendous burden on families and even the whole society. It is urgent to find out effective drugs without side effects. The present study applied a creative approach called network pharmacology to explore the active compounds and therapeutic targets of Shaoyao-Gancao Decoction (SYGCD) for treating PD. We identified a total of 48 active compounds mediating 30 PD-related targets to exert synergism, and the same target can be enriched in multiple signal pathways and biological processes, expounding that the decoction can exert synergistic effect on PD by multi-targets and multi-pathways. Furthermore, the molecular docking analysis showed that active compounds and targets can be well combined. These results highlighted the molecular mechanisms underlying the efficiency of SYGCD for PD treatment at a systematic level, investigating thoroughly the innovative therapeutic tactics for PD in traditional Chinese medicine.

中文翻译：

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基于网络药理学的Sha药-甘草汤治疗帕金森病分子机制的研究。

帕金森氏病（PD）是继阿尔茨海默氏病之后的另一种主要的神经退行性疾病，不仅严重降低了患者的生存率，影响了患者的生活质量，而且给家庭乃至整个社会带来了沉重负担。迫切需要找到没有副作用的有效药物。本研究采用了一种创新的方法，称为网络药理学，以探索oy药-甘草汤（SYGCD）的有效成分和治疗靶点。我们共鉴定出48种活性化合物，介导30种与PD相关的靶标发挥协同作用，并且同一靶标可在多种信号途径和生物过程中富集，说明该汤可通过多靶点和多靶点对PD发挥协同作用。途径。此外，分子对接分析表明活性化合物和靶标可以很好地结合。这些结果突显了SYGCD在PD上有效治疗PD的分子机制，并彻底研究了中药PD的创新治疗策略。