Previous studies have shown that alterations in the mechanical properties of cells may be associated with the onset and progression of some forms of pathology. In this paper, an experimental study of two types of cells, renal (cancer) and bladder (cancer) cells, is described which used acoustic radiation force (ARF) generated by a high-frequency ultrasound focusing transducer and performed on the operating platform of an inverted light microscope. Comparing images of cancer cells with those of normal cells of the same kind, we find that the cancer cells are more prone to deform than normal cells of the same kind under the same ARF. In addition, cancer cells with higher malignancy are more deformable than those with lower malignancy. This means that the deformability of cells may be used to distinguish diseased cells from normal ones, and more aggressive cells from less aggressive ones, which may provide a more rapid and accurate method for clinical diagnosis of urological disease in the future.

中文翻译：

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声辐射力诱发正常细胞与病理细胞，肾脏和膀胱细胞变形差异的实验研究。

先前的研究表明，细胞机械特性的改变可能与某些病理形式的发生和发展有关。在本文中，我们描述了两种类型的细胞的实验研究，即肾（癌细胞）和膀胱（癌细胞）两种细胞，它们利用高频超声聚焦换能器产生的声辐射力（ARF）并在细胞的操作平台上进行倒置光学显微镜。比较癌细胞和同类正常细胞的图像，我们发现在相同的ARF下，癌细胞比同类正常细胞更容易变形。另外，具有较高恶性的癌细胞比具有较低恶性的癌细胞更易变形。这意味着细胞的可变形性可用于区分患病细胞与正常细胞，