Bipolar Disorder (BD) is a chronic a multifactorial psychiatric illness that affects mood, cognition, and functioning. BD is associated with several psychiatric conditions as well clinical comorbidities, particularly cardiovascular diseases. The neurobiology of BD is complex and multifactorial and several systems have been implicated. Considering that the Renin Angiotensin System (RAS) plays an important role in cardiovascular diseases and that recently evidence has suggested its role in psychiatric disorders, the aim of the present study is to summarize and to discuss recent findings related to the modulation of RAS components in BD. A systematic search of the literature using the electronic databases MEDLINE and LILACS was conducted through March 2019. The search terms were: “Bipolar Disorder”; “Renin Angiotensin System”; “Angiotensin 2”; “Angiotensin receptors”; “Angiotensin 1-7”; “ACE”; “ACE2”; “Mas Receptor”. We included original studies assessing RAS in BD patients. Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. In the majority of studies (6 of 8), the ACE insertion/deletion (I/D) polymorphism did not differ between BD patients and controls. BD patients presented higher plasma renin activity in comparison with controls. The studies evaluating the RAS molecules in BD are very scarce and heterogeneous. The literature suggests a potential role of RAS in BD. Further studies are necessary to investigate this relationship.

躁郁症（BD）是一种慢性多因素精神病，会影响情绪，认知和功能。BD与多种精神疾病以及临床合并症（尤其是心血管疾病）相关。BD的神经生物学是复杂和多因素的，并且涉及多个系统。考虑到肾素血管紧张素系统（RAS）在心血管疾病中起着重要作用，并且最近有证据表明其在精神疾病中的作用，本研究的目的是总结和讨论与RAS成分调节有关的最新发现。 BD。到2019年3月，使用MEDLINE和LILACS电子数据库对文献进行了系统的检索。“肾素血管紧张素系统”；“血管紧张素2”；“血管紧张素受体”；“血管紧张素1-7”；“高手”; “ ACE2”；“受体”。我们纳入了评估BD患者RAS的原始研究。最初检索到22条引用。我们的系统评价包括11项研究。在大多数研究（8中的6个）中，BD患者和对照组之间的ACE插入/缺失（I / D）多态性没有差异。与对照组相比，BD患者的血浆肾素活性更高。评估BD中RAS分子的研究非常稀少且异质。文献表明RAS在BD中具有潜在作用。有必要进一步研究以研究这种关系。我们的系统评价包括11项研究。在大多数研究（8中的6个）中，BD患者和对照组之间的ACE插入/缺失（I / D）多态性没有差异。与对照组相比，BD患者的血浆肾素活性更高。评估BD中RAS分子的研究非常稀少且异质。文献表明RAS在BD中具有潜在作用。有必要进一步研究以研究这种关系。我们的系统评价包括11项研究。在大多数研究（8中的6个）中，BD患者和对照组之间的ACE插入/缺失（I / D）多态性没有差异。与对照组相比，BD患者的血浆肾素活性更高。评估BD中RAS分子的研究非常稀少且异质。文献表明RAS在BD中具有潜在作用。有必要进一步研究以研究这种关系。