Scrub typhus has re-emerged as an important cause of acute febrile illness in India. There is a dearth of information on strain diversity of Orientia tsutsugamushi from Karnataka, India, hence the present study sought to address this issue. One hundred clinically suspected cases of scrub typhus/rickettsiosis (as per the DHR-ICMR guidelines) were included. Nested-polymerase chain reaction (PCR) for 56-kDa gene and phylogenetic analysis was performed. PCR was positive in 22 cases and phylogenetic analysis showed the presence of different strains, with predominance of clustering (57%) with Gilliam-type for the first time in Karnataka. Knowledge of genetic diversity has implications in development of diagnostics and vaccine.

中文翻译：

---

印度班加罗尔恙虫病东方体分离株的系统发育多样性。


恙虫病重新成为印度急性发热性疾病的重要病因。关于印度卡纳塔克邦恙虫病东方体菌株多样性的信息缺乏，因此本研究试图解决这个问题。纳入了 100 例临床疑似恙虫病/立克次体病病例（根据 DHR-ICMR 指南）。对 56-kDa 基因进行巢式聚合酶链反应 (PCR) 和系统发育分析。 22 例 PCR 呈阳性，系统发育分析显示存在不同菌株，其中在卡纳塔克邦首次以 Gilliam 型为优势聚类（57%）。遗传多样性的知识对诊断和疫苗的开发具有重要意义。