Introduction Central venous catheters (CVCs) implanted in patients with malignancies may often be associated with local or central line-associated bloodstream infections (CLABSI), which are a major source of morbidity and rarely mortality, making such patients' care difficult and complicated. Materials and Methods This retrospective study is a single-centre's experience including both paediatric and adult patients with malignancy, who had a CVC inserted and were receiving care at cancer centre of our hospital over a period between January 2017 and June 2018. Results In the period from January 2017 to June 2018, 73 confirmed cases of CLABSIs among cancer patients were included in this study. The rate of CLABSIs was estimated as 2.1 episodes/1000 CVC days. Out of 73 CLABSI cases, Gram-negative bacilli were the predominant causative agents of CLABSI constituting 72.6% (n = 53/73) of isolated organisms, 21.9% (n = 16/73) of infections were caused by Gram-positive cocci while polymicrobial infections accounted for 5.4% (n = 4/73) of these cases. Conclusion Over the last 20 years, an epidemiologic shift has occurred among CLABSI in cancer patients. These findings should be considered with the development of interventions that will prevent Gram-negative CLABSI after CVC insertion. To our knowledge, this is the first study reporting data on the incidence of CLABSIs in cancer patients at tertiary care hospital from North Indian hospital.

中文翻译：

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癌症患者中与中心静脉导管相关的血流感染：来自三级护理癌症中心的经验。


简介 恶性肿瘤患者植入的中心静脉导管 (CVC) 通常可能与局部或中心静脉导管相关血流感染 (CLABSI) 相关，这是发病率和很少死亡的主要来源，使此类患者的护理变得困难和复杂。材料和方法这项回顾性研究是一项单中心的经验，包括 2017 年 1 月至 2018 年 6 月期间在我院癌症中心接受 CVC 插入的儿童和成人恶性肿瘤患者。该研究纳入了2017年1月至2018年6月期间73例确诊的癌症患者CLABSI病例。 CLABSI 发生率估计为 2.1 次/1000 CVC 天。在 73 例 CLABSI 病例中，革兰氏阴性杆菌是 CLABSI 的主要病原体，占分离微生物的 72.6% (n = 53/73)，21.9% (n = 16/73) 的感染由革兰氏阳性球菌引起，而多种微生物感染占这些病例的 5.4% (n = 4/73)。结论 过去 20 年来，癌症患者 CLABSI 的流行病学发生了转变。在制定预防 CVC 插入后革兰氏阴性 CLABSI 的干预措施时应考虑这些发现。据我们所知，这是第一项报告北印度医院三级医院癌症患者 CLABSI 发病率数据的研究。