Purpose This study was carried out to determine the seroprevalence of anti-Toxoplasma gondii antibodies in different groups of patients at a tertiary care hospital in North India. Materials and Methods Clinical and demographic data such as age and gender of patients who had undergone testing for the presence of anti-T. gondii IgG and IgM antibodies between January 2004 and October 2014 were retrospectively analysed. Results Amongst the 8397 serum samples, an overall seropositivity of 21% (n = 1763) and IgG and IgM seropositivity of 5.7% (n = 481) and 15.3% (n = 1282) were respectively observed. Compared to the period of 2004-2012 (median seroprevalence: 23.6%), a decline in seropositivity to 9.7% in 2013 and 8.1% in 2014 was noted. A rising seroprevalence with age and a higher seroprevalence in females versus males (29.5%, n = 1179 vs. 13.3%, n = 584) were recorded. The highest seroprevalence was observed in suspected ocular toxoplasmosis (47.2%, n = 47), followed by neurological (26.8%, n = 77), human immunodeficiency virus/acquired immunodeficiency syndrome (18.9%, n = 267), post-transplant (17.1%, n = 12) and congenital (7.2%, n = 144) toxoplasmosis. In patients screened for Toxoplasma exposure, the seropositivity was 47.8% (n = 11) in transplant screening and 44.9% (n = 781) in antenatal screening. Conclusion Toxoplasma infection is highly prevalent in the population of North India across various clinical categories of patients. Future studies focusing on continuous monitoring of seroprevalence trends and elucidation of the risk factors associated with seropositivity in more defined groups of patients are needed.

中文翻译：

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2004 年至 2014 年印度北部三级护理中心的弓形虫病血清阳性率。


目的 本研究旨在确定印度北部一家三级护理医院不同患者群体中抗弓形虫抗体的血清阳性率。材料和方法接受过抗 T 蛋白检测的患者的临床和人口统计数据，例如年龄和性别。回顾性分析2004年1月至2014年10月弓形虫IgG和IgM抗体。结果 8397份血清样本中，总体血清阳性率为21%（n = 1763），IgG和IgM血清阳性率分别为5.7%（n = 481）和15.3%（n = 1282）。与 2004-2012 年期间（中位血清阳性率：23.6%）相比，血清阳性率在 2013 年下降至 9.7%，在 2014 年下降至 8.1%。血清阳性率随着年龄的增长而上升，女性血清阳性率高于男性（29.5%，n = 1179 vs. 13.3%，n = 584）。疑似眼弓形虫病的血清阳性率最高（47.2%，n = 47），其次是神经系统疾病（26.8%，n = 77）、人类免疫缺陷病毒/获得性免疫缺陷综合征（18.9%，n = 267）、移植后（ 17.1%，n = 12）和先天性（7.2%，n = 144）弓形虫病。在接受弓形虫暴露筛查的患者中，移植筛查中的血清阳性率为 47.8% (n = 11)，产前筛查中的血清阳性率为 44.9% (n = 781)。结论 弓形虫感染在印度北部人群中各种临床类别的患者中非常普遍。未来的研究需要集中于持续监测血清阳性率趋势并阐明与更明确的患者群体中血清阳性相关的危险因素。