The laccase (Lac), manganese peroxidases (MnP), and lignin peroxidase enzymes produced by basidiomycete have been studied due to their potential in bioremediation, therefore, in this study, degradation of diclofenac (DCF), sulfamethoxazole (SMX), indomethacin (IND), gemfibrozil (GFB), and bezafibrate (BZF) by enzymes produced by Trametes maxima, Pleurotus sp., and Pycnosporus sanguineus grown in culture was evaluated. The degradation of drugs can mainly be attributed to MnP because a correlation between the activity of this enzyme and the degree of removal was found. The specific activity of Lac did not show correlation with drug removal, while lignin peroxidase was not expressed. Trametes maxima showed the highest specific activity of MnP (387.6 ± 67.4 U/mg) and efficiency removal 90.2% of DCF, 72.62% of SMX, 60.76% of IND, 43.39% of GFB, and 32.59% of BZF) followed by Pleurotus sp. with specific activity of MnP of 55.9 ± 8.5 U/mg and 89.47% of DCF, 47.61% of GFB and 73% of IND were removed, P. sanguineus had the lowest specific activity of 18 ± 1.3 U/mg and was able to remove only 42% of SMX and 10.59% of IND. In order to prove that MnP remove drugs instead of Lac, the pure Lac was tested and only degraded DCF.

由于担子菌具有生物修复潜力，因此已经研究了担子菌产生的漆酶（Lac），锰过氧化物酶（MnP）和木质素过氧化物酶，因此，在本研究中，双氯芬酸（DCF），磺胺甲恶唑（SMX），消炎痛（IND）的降解），通过培养中生长的Trametes maxima，Pleurotus sp。和Pycnosporus sanguineus产生的酶评估了吉非贝齐（GFB）和苯扎贝特（BZF）。药物的降解主要归因于MnP，因为发现了该酶的活性与去除程度之间的相关性。Lac的比活性与药物去除没有相关性，而木质素过氧化物酶未表达。最大值表明锰过氧化物酶的最高比活性（387.6±67.4 U / mg）和效率去除DCF的90.2％，SMX的72.62％，IND的60.76％，GFB的43.39％，和BZF的32.59％），其次是侧耳属。MnP的比活度为55.9±8.5 U / mg，DCF的89.47％，去除了47.61％的GFB和73％的IND，血红假单胞菌的最低比活度为18±1.3 U / mg，能够去除仅SMX的42％和IND的10.59％。为了证明MnP可以代替Lac去除药物，测试了纯Lac，仅降解了DCF。