The purpose of the study was to investigate the association between infectious agents and the development of cancer in the ocular adnexa. A comprehensive literary study was carried out, reviewing and summarizing previous reports on the topic. A broad range of malignancies of the ocular adnexa are associated with infectious agents. A strong association and possible causal relationship between the infectious agent and the development of ocular adnexal cancer are seen in Merkel cell carcinoma (Merkel cell polyomavirus), Burkitt lymphoma (Epstein-Barr virus) and Kaposi sarcoma (human herpesvirus 8). Infection with Chlamydia psittaci has been associated with the development of extranodal marginal zone B-cell lymphoma in Italy. Human papillomavirus infection has been associated with the development of squamous cell carcinomas of the ocular adnexa, although with a highly variable reported prevalence. By exploring the role of infectious agents in the ocular adnexa and the mechanism by which they contribute to oncogenesis, the diagnostics, management and prevention of these malignancies may also improve. Antibiotic treatment and vaccines against infectious agents may be valuable in future treatment. Additionally, the presence of infectious agents within the tumours may have a prognostic or predictive value.

中文翻译：

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感染剂在眼部癌症中的作用。

该研究的目的是研究眼球附件中感染因子与癌症发展之间的关系。进行了全面的文学研究，回顾和总结了有关该主题的先前报告。眼部附件的各种恶性肿瘤均与传染原有关。在默克尔细胞癌（默克尔细胞多瘤病毒），伯基特淋巴瘤（Epstein-Barr病毒）和卡波西肉瘤（人类疱疹病毒8）中发现了感染因素与眼附件癌的发展之间的密切关联，并可能存在因果关系。在意大利，鹦鹉热衣原体感染与结外边缘区B细胞淋巴瘤的发生有关。人乳头瘤病毒感染已与眼附件的鳞状细胞癌的发展有关，尽管报告的患病率变化很大。通过探索感染剂在眼附件中的作用以及它们促成肿瘤的机制，这些恶性肿瘤的诊断，管理和预防也可能得到改善。抗生素治疗和抗感染剂疫苗可能在将来的治疗中有价值。另外，肿瘤内感染因子的存在可能具有预后或预测价值。