Oxidative stress and neuroinflammation are closely related to the pathological processes of neurological disorders. Peroxiredoxin 2 (Prdx2) is an abundant antioxidant enzyme in the central nervous system. Prdx2 reduces the production of reactive oxygen species and participates in regulating various signaling pathways in neurons by catalyzing hydrogen peroxide (H2O2), thereby protecting neurons against oxidative stress and an inflammatory injury. However, the spillage of Prdx2, as damage-associated molecular patterns, accelerates brain damage after stroke by activating an inflammatory response. The post-translational modifications of Prdx2 also affect its enzyme activity. This review focuses on the effects of Prdx2 and its molecular mechanisms in various neurological disorders.

中文翻译：

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Peroxiredoxin 2在神经系统疾病中的作用：其分子机制的审查。

氧化应激和神经炎症与神经系统疾病的病理过程密切相关。Peroxiredoxin 2（Prdx2）是中枢神经系统中一种丰富的抗氧化酶。Prdx2减少了活性氧的产生，并通过催化过氧化氢（H2O2）参与调节神经元中的各种信号传导途径，从而保护神经元免受氧化应激和炎症性损伤。但是，作为损伤相关分子模式的Prdx2的溢出，通过激活炎症反应而加速了中风后的脑损伤。Prdx2的翻译后修饰也影响其酶活性。这篇综述着重介绍了Prdx2在各种神经系统疾病中的作用及其分子机制。