Deep brain stimulation (DBS) is an established therapy for movement disorders such as essential tremor (ET). Positioning of the DBS lead in the patient's brain is crucial for effective treatment. Extensive evaluations of improvement and adverse effects of stimulation at different positions for various current amplitudes are performed intraoperatively. However, to choose the optimal position of the lead, the information has to be "mentally" visualized and analyzed. This paper introduces a new technique called "stimulation maps," which summarizes and visualizes the high amount of relevant data with the aim to assist in identifying the optimal DBS lead position. It combines three methods: outlines of the relevant anatomical structures, quantitative symptom evaluation, and patient-specific electric field simulations. Through this combination, each voxel in the stimulation region is assigned one value of symptom improvement, resulting in the division of stimulation region into areas with different improvement levels. This technique was applied retrospectively to five ET patients in the University Hospital in Clermont-Ferrand, France. Apart from identifying the optimal implant position, the resultant nine maps show that the highest improvement region is frequently in the posterior subthalamic area. The results demonstrate the utility of the stimulation maps in identifying the optimal implant position. Graphical abstract.

中文翻译：

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刺激图：深部脑刺激手术术中定量术中测试结果的可视化。

深部脑刺激（DBS）是一种针对运动障碍（例如原发性震颤（ET））的公认疗法。DBS导线在患者大脑中的位置对于有效治疗至关重要。术中对不同电流幅度在不同位置刺激的改善和不良影响进行了广泛的评估。但是，要选择导线的最佳位置，必须“智能地”可视化和分析信息。本文介绍了一种称为“刺激图”的新技术，该技术可以汇总和可视化大量相关数据，以帮助确定最佳的DBS引线位置。它结合了三种方法：有关解剖结构的概述，定量症状评估和特定于患者的电场模拟。通过这种组合，刺激区域中的每个体素被分配一个症状改善值，从而将刺激区域划分为具有不同改善水平的区域。这项技术被追溯应用于法国克莱蒙费朗的大学医院的五名ET患者。除了确定最佳的植入位置外，所得的九幅图还表明，最大的改善区域通常位于丘脑后部区域。结果证明了刺激图在识别最佳植入物位置中的实用性。图形概要。这项技术被追溯应用于法国克莱蒙费朗的大学医院的五名ET患者。除了确定最佳的植入位置外，所得的九幅图还表明，最大的改善区域通常位于丘脑后部区域。结果证明了刺激图在确定最佳植入物位置方面的实用性。图形概要。这项技术被追溯应用于法国克莱蒙费朗的大学医院的五名ET患者。除了确定最佳的植入位置外，所得的九幅图还表明，最大的改善区域通常位于丘脑后部区域。结果证明了刺激图在识别最佳植入物位置中的实用性。图形概要。