Solute carrier (SLC) transporters meditate many essential physiological functions, including nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and infections, the mammalian immune system coordinates complex signals to support the proliferation, differentiation, and effector function of individual cell subsets. Recent research in this area has yielded surprising findings on the roles of solute carrier transporters, which were discovered to regulate lymphocyte signaling and control their differentiation, function, and fate by modulating diverse metabolic pathways and balanced levels of different metabolites. In this review, we present current information mainly on glucose transporters, amino-acid transporters, and metal ion transporters, which are critically important for mediating immune cell homeostasis in many different pathological conditions.

中文翻译：

---

溶质载体转运蛋白：免疫细胞的代谢守门人。

溶质载体（SLC）转运蛋白可冥想许多基本的生理功能，包括营养吸收，离子流入/流出和废物处置。哺乳动物免疫系统以其对肿瘤和感染的保护作用来协调复杂信号，以支持单个细胞亚群的增殖，分化和效应子功能。在该领域的最新研究已得出关于溶质载体转运蛋白作用的令人惊讶的发现，溶质载体转运蛋白通过调节多种代谢途径和平衡的不同代谢产物水平来调节淋巴细胞信号传导并控制其分化，功能和命运。在这篇评论中，我们主要介绍有关葡萄糖转运蛋白，氨基酸转运蛋白和金属离子转运蛋白的最新信息，