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Epidemiology of major chronic inflammatory immune-related skin diseases in 2019.
Expert Review of Clinical Immunology ( IF 3.9 ) Pub Date : 2020-01-28 , DOI: 10.1080/1744666x.2020.1719833
Elena Pezzolo 1, 2 , Luigi Naldi 1, 2
Affiliation  

Introduction: 'Chronic inflammatory immune-related skin disease' (ISDs) is an umbrella term grouping together heterogeneous entities characterized by chronic inflammation potentially involving the whole skin. We are not covering all ISDs in this review, but take a few as the most representative, including nonbullous and bullous diseases. The question we are aiming to address can be summarized as follows: 'despite the differences, is it possible to define some unifying epidemiologic characteristics and shared progression pathways which can guide the organization of healthcare?'Areas covered: This review covers incidence, prevalence, risk factors and prognosis of psoriasis, atopic dermatitis (AD), pemphigus and pemphigoid. Medline, Embase and the Cochrane Library were searched for papers published between January 2005 and December 2019.Expert opinion: ISDs epidemiology varies according to the ISD type, age, sex, climate, and sociodemographic variables. AD and psoriasis pose a considerable public health burden owing to their high prevalence worldwide and morbidity. Their secular trend of increasing incidence points to a role for environmental factors and gene-environment interactions. Bullous diseases are much rarer, with limited data available. Worldwide, the leading cause of skin disease disability-adjusted life-years (DALYs) is attributable to AD. Future research should focus on risk factors and prevention at the global level.

中文翻译:

2019年主要的慢性炎症性免疫相关皮肤病的流行病学。

简介:“慢性炎症性免疫相关皮肤病”(ISD)是一个总括性术语,将以慢性炎症为特征的异质实体组合在一起,潜在地涉及整个皮肤。在本次审查中,我们并未涵盖所有ISD,但其中一些是最具代表性的,包括非球形和大疱性疾病。我们旨在解决的问题可以概括如下:“尽管存在差异,是否有可能定义一些统一的流行病学特征和共同的进展路径来指导医疗保健的组织?”涵盖的领域:本次审查涵盖了发病率,患病率,牛皮癣,特应性皮炎(AD),天疱疮和天疱疮的危险因素和预后。Medline,搜寻Embase和Cochrane图书馆2005年1月至2019年12月之间发表的论文。专家意见:ISD的流行病学因ISD的类型,年龄,性别,气候和社会人口统计学变量而异。由于AD和牛皮癣在世界范围内的高流行和发病率,给公共卫生负担相当大。它们发生率的长期趋势表明环境因素和基因-环境相互作用的作用。大流行性疾病很少见,可用数据有限。在世界范围内,皮肤病致残调整生命年(DALYs)的主要原因是AD。未来的研究应关注全球范围内的风险因素和预防。由于AD和牛皮癣在世界范围内的高流行和发病率,给公共卫生负担相当大。它们发生率的长期趋势表明环境因素和基因-环境相互作用的作用。大流行性疾病很少见,可用数据有限。在世界范围内,皮肤病致残调整生命年(DALYs)的主要原因是AD。未来的研究应关注全球范围内的风险因素和预防。由于AD和牛皮癣在世界范围内的高流行和发病率,给公共卫生负担相当大。它们发生率的长期趋势表明环境因素和基因-环境相互作用的作用。大流行性疾病很少见,可用数据有限。在世界范围内,皮肤病致残调整生命年(DALYs)的主要原因是AD。未来的研究应关注全球范围内的风险因素和预防。皮肤病致残调整生命年(DALYs)的主要原因是AD。未来的研究应关注全球范围内的风险因素和预防。皮肤病致残调整生命年(DALYs)的主要原因是AD。未来的研究应关注全球范围内的风险因素和预防。
更新日期:2020-03-26
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