Introduction: Although successful at suppressing HIV replication, combination antiretroviral therapy (cART) only partially restores immune functions and fails to reduce the latent HIV reservoir, thus requiring novel interventions for its intensification.Areas covered: Here are reviewed therapeutic vaccine candidates that are being developed to this goal. Among them, the Tat vaccine has been shown to promote immune restoration, including CD4+ T-cell recovery in low immunological responders, and to reduce the virus reservoirs well beyond what achieved with long-term suppressive cART.Expert opinion: The authors propose the Tat vaccine as a promising vaccine candidate for cART intensification toward HIV reservoirs depletion, functional cure, and eradication strategies, suggesting that targeting a key protein in the virus life cycle is pivotal to success.

中文翻译：

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HIV治疗疫苗旨在加强联合抗逆转录病毒治疗。

简介：虽然成功地抑制了HIV的复制，但联合抗逆转录病毒疗法（cART）只能部分恢复免疫功能并且不能减少潜在的HIV储库，因此需要对其进行强化的新干预措施。为了这个目标。其中，Tat疫苗已被证明可以促进免疫恢复，包括在低免疫应答者中恢复CD4 + T细胞，并减少病毒库，远远超出了长期抑制性cART所能达到的效果。这种疫苗有望成为针对HIV储存库耗竭，功能治愈和根除策略的cART强化的有希望的候选疫苗，