Sleep plays an important role in regulating plasticity. In Drosophila, the relationship between sleep and learning and memory has primarily focused on mushroom body dependent operant-learning assays such as aversive phototaxic suppression and courtship conditioning. In this study, sleep was increased in the classic mutant rutabaga (rut2080) and dunce (dnc1) by feeding them the GABA-A agonist gaboxadol (Gab). Performance was evaluated in each mutant in response to social enrichment and place learning, tasks that do not require the mushroom body. Gab-induced sleep did not restore behavioral plasticity to either rut2080 or dnc1 mutants following social enrichment. However, increased sleep restored place learning to rut2080 mutants. These data extend the positive effects of enhanced sleep to place learning and highlight the utility of Gab for elucidating the beneficial effects of sleep on brain functioning.

中文翻译：

---

睡眠可以恢复腺苷酸环化酶突变体芜菁甘蓝的学习能力。


睡眠在调节可塑性方面发挥着重要作用。在果蝇中，睡眠与学习和记忆之间的关系主要集中在蘑菇体依赖的操作性学习测定上，例如厌恶趋光抑制和求偶条件反射。在这项研究中，通过给经典突变体芜菁甘蓝 (rut2080) 和笨蛋 (dnc1) 喂食 GABA-A 激动剂加波沙朵 (Gab)，它们的睡眠时间得到了增加。针对社交丰富和场所学习以及不需要蘑菇体的任务，对每个突变体的表现进行了评估。 Gab 诱导的睡眠并没有恢复 rut2080 或 dnc1 突变体在社交丰富后的行为可塑性。然而，增加睡眠可以恢复 rut2080 突变体的学习能力。这些数据扩展了增强睡眠对学习的积极影响，并强调了 Gab 在阐明睡眠对大脑功能的有益影响方面的实用性。