OBJECTIVE The purposes of this study are to evaluate which growth plate parameters are associated with bone growth in mice and to compare the mouse results with those in humans. DESIGN The sagittal sections of the proximal growth plate of the mouse tibia from neonate to young adult stages were subjected to histomorphometric and functional analyses. The radiographic images of tibias of human patients until puberty were analyzed to obtain the tibia length and the proximal growth plate height. It was found that a linear correlation best modeled the relationship between the growth plate variables with the tibia growth rate and length. RESULTS In mice, total height, resting zone height, combined height of the proliferation and prehypertrophic zones, proliferation activity, and the total width of tibia growth plate showed high linear correlation with tibia bone length and bone growth rate, but the hypertrophic zone height and the growth plate area did not. In both mice and humans, the total growth plate width of tibia was found to have the strongest correlation with tibia length and growth rate. CONCLUSIONS The results validated that growth plate total height, the height of the resting zone and cell proliferation activity are appropriate parameters to evaluate the balance between growth plate activity and bone growth in mice, consistent with previous reports. The study also provided a new growth plate parameter candidate, growth plate width for growth plate activity evaluation in both mouse and human tibia bone.

中文翻译：

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人鼠生长板形态参数与胫骨骨生长的关联分析。

目的 本研究的目的是评估哪些生长板参数与小鼠骨骼生长相关，并将小鼠结果与人类结果进行比较。设计 对从新生儿到青年阶段的小鼠胫骨近端生长板的矢状切片进行组织形态学和功能分析。分析人类患者直到青春期的胫骨的放射影像，以获得胫骨长度和近端生长板高度。发现线性相关最好地模拟了生长板变量与胫骨生长速率和长度之间的关系。结果 在小鼠中，总高度、静息区高度、增殖和肥大前区的组合高度、增殖活性、胫骨生长板总宽度与胫骨骨长和骨生长速度呈高度线性相关，而肥大区高度和生长板面积则没有。在小鼠和人类中，发现胫骨的总生长板宽度与胫骨长度和生长速率的相关性最强。结论结果验证了生长板总高度、静止区高度和细胞增殖活性是评价小鼠生长板活性与骨生长平衡的合适参数，与以往报道一致。该研究还提供了一种新的生长板参数候选者，即生长板宽度，用于评估小鼠和人类胫骨的生长板活性。在小鼠和人类中，发现胫骨的总生长板宽度与胫骨长度和生长速率的相关性最强。结论结果验证了生长板总高度、静止区高度和细胞增殖活性是评价小鼠生长板活性与骨生长平衡的合适参数，与以往报道一致。该研究还提供了一种新的生长板参数候选者，即生长板宽度，用于评估小鼠和人类胫骨的生长板活性。在小鼠和人类中，发现胫骨的总生长板宽度与胫骨长度和生长速率的相关性最强。结论结果验证了生长板总高度、静止区高度和细胞增殖活性是评价小鼠生长板活性与骨生长平衡的合适参数，与以往报道一致。该研究还提供了一种新的生长板参数候选者，即生长板宽度，用于评估小鼠和人类胫骨的生长板活性。静止区的高度和细胞增殖活性是评估小鼠生长板活性和骨骼生长之间平衡的适当参数，与先前的报道一致。该研究还提供了一种新的生长板参数候选者，即生长板宽度，用于评估小鼠和人类胫骨的生长板活性。静止区的高度和细胞增殖活性是评估小鼠生长板活性和骨骼生长之间平衡的适当参数，与先前的报道一致。该研究还提供了一种新的生长板参数候选者，即生长板宽度，用于评估小鼠和人类胫骨的生长板活性。