A Phytophthora capsici effector suppresses plant immunity via interaction with EDS1.,Molecular Plant Pathology

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A Phytophthora capsici effector suppresses plant immunity via interaction with EDS1.
Molecular Plant Pathology ( IF 4.8 ) Pub Date : 2020-01-29 , DOI: 10.1111/mpp.12912
Qi Li _{1,

2} , Ji Wang ₁ , Tian Bai ₁ , Ming Zhang ₁ , Yuling Jia ₁ , Danyu Shen ₁ , Meixiang Zhang ₁ , Daolong Dou ₁

Affiliation

EDS1 (Enhanced Disease Susceptibility 1) plays a crucial role in both effector‐triggered immunity activation and plant basal defence. However, whether pathogen effectors can target EDS1 or an EDS1‐related pathway to manipulate immunity is rarely reported. In this study, we identified a Phytophthora capsici Avirulence Homolog (Avh) RxLR (Arg‐any amino acid‐Leu‐Arg) effector PcAvh103 that interacts with EDS1. We demonstrated that PcAvh103 can facilitate P. capsici infection and is required for pathogen virulence. Furthermore, genetic evidence showed that PcAvh103 contributes to virulence through targeting EDS1. Finally, PcAvh103 specifically interacts with the lipase domain of EDS1 and can promote the disassociation of EDS1–PAD4 (Phytoalexin Deficient 4) complex in planta. Together, our results revealed that the P. capsici RxLR effector PcAvh103 targets host EDS1 to suppress plant immunity, probably through disrupting the EDS1–PAD4 immune signalling pathway.

中文翻译：

辣椒疫霉效应子通过与EDS1的相互作用抑制植物的免疫力。

EDS1（增强的疾病易感性1）在效应子触发的免疫激活和植物基础防御中都起着至关重要的作用。但是，很少有病原体效应子可以靶向EDS1或EDS1相关途径来操纵免疫。在这项研究中，我们确定了与EDS1相互作用的辣椒疫霉无毒同源蛋白（Avh）RxLR（Arg-任何氨基酸-Leu-Arg）效应物PcAvh103。我们证实了PcAvh103可以促进辣椒疫霉感染，是病原体毒力所必需的。此外，遗传证据表明PcAvh103通过靶向EDS1促进了毒力。最后，PcAvh103与EDS1的脂肪酶结构域特异性相互作用，并可以促进植物体内EDS1-PAD4（植物抗毒素缺乏4）复合物的解离。总之，我们的结果表明，辣椒疫霉RXLR效应PcAvh103目标主机EDS1来抑制植物免疫，可能是通过破坏EDS1，PAD4免疫信号通路。

更新日期：2020-01-29

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