We investigated quality of life (WHOQoL-BREF), perceived stress (PSS-10), anxiety and depression (HADS-M), life satisfaction (SWLS), and serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and cortisol in family caregivers (n = 94) and professional caregivers (n = 48) of demented patients, as well as among noncaregivers (n = 30). Compared with professional caregivers, family caregivers had higher scores in HADS-M depression (P = .003) and anxiety (P = .033), lower life satisfaction (P = .04), and lower quality of life in psychological (P = .02) and social relationship (P = .03) domains. There were no differences in serum levels of IL-6, CRP, or cortisol between caregivers and control participants. In multivariable analysis, when family relationship was considered together with the time period of caregiving and results of the Mini-Mental State Examination test in care recipients (n = 118, 12.49 ± 7.99), only family relationship influenced scores in HADS-M depression (P = .004), SWLS scores (P = .011), and WHOQoL-BREF scores in psychological (P = .011) and social relationship (P = .008) domains. In conclusion, family caregivers are more stressed and have deeper depressive and anxiety disorders, lower life satisfaction, and lower quality of life than professional caregivers.

中文翻译：

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家庭与失智症患者的非家庭照护者相比，抑郁症的症状有所增加，但炎症指标却没有增加。

我们调查了生活质量（WHOQoL-BREF），感知压力（PSS-10），焦虑和抑郁（HADS-M），生活满意度（SWLS）和血清白细胞介素6（IL-6），C反应性痴呆患者的家庭护理人员（n = 94）和专业护理人员（n = 48）以及非护理人员（n = 30）中的蛋白质（CRP）和皮质醇。与专业护理人员相比，家庭护理人员在HADS-M抑郁（P = .003）和焦虑（P = .033），生活满意度（P = .04）和心理生活质量（P = .02）和社会关系（P = .03）域。在看护人和对照组之间，血清IL-6，CRP或皮质醇水平没有差异。在多变量分析中，当考虑家庭关系以及护理时间和接受护理者的小精神状态检查测试的结果（n = 118，12.49±7.99）时，只有家庭关系会影响HADS-M抑郁的得分（P = 0.004） ），SWLS得分（P = .011）和WHOQoL-BREF得分在心理领域（P = .011）和社会关系领域（P = .008）。总之，与专业护理人员相比，家庭护理人员的压力更大，抑郁和焦虑症更深，生活满意度较低，生活质量较低。