Recent interest in developing new regenerative medicine- and tissue engineering-based treatments has motivated researchers to develop strategies for manipulating stem cells to optimize outcomes in these potentially, game-changing treatments. Cells communicate with each other, and with their surrounding tissues and organs via electrochemical signals. These signals originate from ions passing back and forth through cell membranes and play a key role in regulating cell function during embryonic development, healing, and regeneration. To study the effects of electrical signals on cell function, investigators have exposed cells to exogenous electrical stimulation and have been able to increase, decrease and entirely block cell proliferation, differentiation, migration, alignment, and adherence to scaffold materials. In this review, we discuss research focused on the use of electrical stimulation to manipulate stem cell function with a focus on its incorporation in tissue engineering-based treatments.

最近对开发基于再生医学和组织工程的新疗法的兴趣促使研究人员开发出操纵干细胞的策略，以优化这些可能改变游戏规则的疗法的结果。细胞彼此之间以及与它们周围的组织和器官之间通过电化学信号进行通信。这些信号来自于来回穿过细胞膜的离子，并且在胚胎发育，愈合和再生过程中对调节细胞功能起关键作用。为了研究电信号对细胞功能的影响，研究人员将细胞暴露于外源性电刺激下，能够增加，减少并完全阻断细胞增殖，分化，迁移，排列和对支架材料的粘附。在这篇评论中