Vincristine (VCR)-induced peripheral neuropathy (VIPN) is a common and life-long toxicity in lymphoma patients receiving current standard chemotherapy. The association between VIPN and genetic polymorphisms is largely unknown in adult lymphoma patients. To examine the possible relationship between known genetic polymorphisms in patients with pediatric acute lymphoblastic leukemia and incidence of VIPN in adult patients with B cell lymphoma, we examined CEP72 rs924607, ETAA1 rs17032980, MTNR1B rs12786200, CYP3A5 rs776746, rs7963521, and rs1045644 genetic polymorphisms in samples from 56 adult patients with B-cell lymphoma who received rituximab, cyclophosphamide, doxorubicin, VCR, and prednisone (R-CHOP) chemotherapy. Mutation analysis was performed by direct sequencing. The median age was 65 years (range 30-79). The median cumulative dose of VCR was 12 mg (range 2-16). VIPN was documented in 42 patients (75%), and 9 (16%) had grade 2-4 VIPN. Age, impaired glucose tolerance, number of cycles of R-CHOP, and VCR cumulative dose were not associated with incidence of VIPN. There was no association between the incidence of grade 2-4 or any grade VIPN and these six genetic polymorphisms. These results indicate that CEP72, MTNR1B, ETAA1, CYP3A5, rs7963521, and rs1045644 genetic polymorphisms are not associated with VIPN in patients with B-cell lymphoma who received R-CHOP.

中文翻译：

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接受利妥昔单抗、环磷酰胺、多柔比星、长春新碱和泼尼松治疗的患者的遗传多态性和长春新碱诱导的周围神经病变。

长春新碱 (VCR) 诱导的周围神经病变 (VIPN) 是接受当前标准化疗的淋巴瘤患者常见的终生毒性。VIPN 与遗传多态性之间的关联在成人淋巴瘤患者中很大程度上是未知的。为了检查小儿急性淋巴细胞白血病患者已知基因多态性与成年 B 细胞淋巴瘤患者 VIPN 发病率之间的可能关系，我们检查了样本中的 CEP72 rs924607、ETAA1 rs17032980、MTNR1B rs12786200、CYP3A5 rs776746、rs7963521 和 rs1045644 基因多态性来自 56 名接受利妥昔单抗、环磷酰胺、多柔比星、VCR 和泼尼松 (R-CHOP) 化疗的成年 B 细胞淋巴瘤患者。通过直接测序进行突变分析。中位年龄为 65 岁（范围 30-79）。VCR 的中位累积剂量为 12 mg（范围 2-16）。VIPN 记录在 42 名患者 (75%) 中，9 名 (16%) 有 2-4 级 VIPN。年龄、糖耐量受损、R-CHOP 周期数和 VCR 累积剂量与 VIPN 的发生率无关。2-4级或任何级别VIPN的发生率与这六种遗传多态性之间没有关联。这些结果表明，在接受 R-CHOP 的 B 细胞淋巴瘤患者中，CEP72、MTNR1B、ETAA1、CYP3A5、rs7963521 和 rs1045644 基因多态性与 VIPN 无关。2-4级或任何级别VIPN的发生率与这六种遗传多态性之间没有关联。这些结果表明，在接受 R-CHOP 的 B 细胞淋巴瘤患者中，CEP72、MTNR1B、ETAA1、CYP3A5、rs7963521 和 rs1045644 基因多态性与 VIPN 无关。2-4级或任何级别VIPN的发生率与这六种遗传多态性之间没有关联。这些结果表明，在接受 R-CHOP 的 B 细胞淋巴瘤患者中，CEP72、MTNR1B、ETAA1、CYP3A5、rs7963521 和 rs1045644 基因多态性与 VIPN 无关。