The orbitofrontal cortex extends into the laterally adjacent inferior frontal gyrus. We analyzed how voxel-level functional connectivity of the inferior frontal gyrus and orbitofrontal cortex is related to depression in 282 people with major depressive disorder (125 were unmedicated) and 254 controls, using FDR correction P < 0.05 for pairs of voxels. In the unmedicated group, higher functional connectivity was found of the right inferior frontal gyrus with voxels in the lateral and medial orbitofrontal cortex, cingulate cortex, temporal lobe, angular gyrus, precuneus, hippocampus and frontal gyri. In medicated patients, these functional connectivities were lower and toward those in controls. Functional connectivities between the lateral orbitofrontal cortex and the precuneus, posterior cingulate cortex, inferior frontal gyrus, ventromedial prefrontal cortex and the angular and middle frontal gyri were higher in unmedicated patients, and closer to controls in medicated patients. Medial orbitofrontal cortex voxels had lower functional connectivity with temporal cortex areas, the parahippocampal gyrus and fusiform gyrus, and medication did not result in these being closer to controls. These findings are consistent with the hypothesis that the orbitofrontal cortex is involved in depression, and can influence mood and behavior via the right inferior frontal gyrus, which projects to premotor cortical areas.

中文翻译：

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抑郁症中右下额回和眶额皮质的功能连接。

眶额皮质延伸到横向相邻的下额回。我们使用FDR校正P <0.05对成对体素，分析了282例重度抑郁症患者（125例未接受药物治疗）和254例对照中下额回和眶额皮质的体素水平功能连通性与抑郁的关系。在未用药的组中，发现右下额回具有较高的功能连通性，眶外侧额和内侧眶额皮层，扣带回皮层，颞叶，角回，前胸神经，海马和额回都有体素。在药物治疗患者中，这些功能性连接度较低，且与对照组相比较低。眶外侧额叶皮层与前额突，后扣带状皮层，额下回，在未接受药物治疗的患者中，腹侧前额叶皮层以及前额角和中叶回角较高，而在接受药物治疗的患者中，更接近于对照组。眶额皮质内侧体素与颞皮质区域，海马旁回和梭状回的功能连接性较低，药物治疗并未使它们更接近对照。这些发现与假说是眶额叶皮层参与抑郁症，并可能通过右下额叶回（影响运动皮层区）影响情绪和行为有关。海马旁回和梭形回，药物治疗并未使它们更接近对照。这些发现与眼眶额叶皮层参与抑郁症的假设相符，并且可以通过右下额叶回来影响情绪和行为，该下额叶回伸至运动前皮层区域。海马旁回和梭状回，药物治疗并未使它们更接近对照。这些发现与眼眶额叶皮层参与抑郁症的假设相符，并且可以通过右下额叶回来影响情绪和行为，该下额叶回伸至运动前皮层区域。