mRNA function is controlled by RNA-binding proteins. The specificity of RNA-binding factors for their targets is critical in that it enables all subsequent regulation. Despite widespread recognition of the pervasive role RNA-binding proteins play in development and disease, they remain challenging to target with small molecules. A renaissance in RNA therapeutics has led to the identification of modifications that substantially increase RNA stability. When combined with information regarding specificity, a new class of oligonucleotide mimics has emerged as a means to competitively disrupt the regulation of endogenous substrates. These decoys have been used to inhibit RNA-binding proteins in living animals. Decoys will likely provide new insights into the expansive roles of RNA-binding proteins in biology and disease. Here, we describe examples where they have been used and discuss how they could be applied to new targets.

中文翻译：

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RNA 分子捕获：一种破坏体内蛋白质-RNA 相互作用的新兴工具。

mRNA 功能由 RNA 结合蛋白控制。RNA 结合因子对其靶标的特异性至关重要，因为它能够实现所有后续调控。尽管人们广泛认识到RNA结合蛋白在发育和疾病中发挥的普遍作用，但用小分子靶向它们仍然具有挑战性。RNA 治疗学的复兴导致了对显着提高 RNA 稳定性的修饰的鉴定。当与有关特异性的信息相结合时，一类新的寡核苷酸模拟物已经出现，作为竞争性破坏内源性底物调节的手段。这些诱饵已被用来抑制活体动物中的 RNA 结合蛋白。诱饵可能会为 RNA 结合蛋白在生物学和疾病中的广泛作用提供新的见解。在这里，我们描述了它们的使用示例，并讨论了如何将它们应用于新目标。