The innate immune system is the body's first line of defense against viruses, with pattern recognition receptors (PRRs) recognizing molecules unique to viruses and triggering the expression of interferons and other anti-viral cytokines, leading to the formation of an anti-viral state. The tripartite motif containing 25 (TRIM25) is an E3 ubiquitin ligase thought to be a key component in the activation of signaling by the PRR retinoic acid-inducible gene I protein (RIG-I). TRIM25 has recently been identified as an RNA-binding protein, raising the question of whether its RNA-binding activity is important for its role in innate immunity. Here, we review TRIM25's mechanisms and pathways in noninfected and infected cells. We also introduce models that explain how TRIM25 binding to RNA could modulate its functions and play part in the antiviral response. These findings have opened new lines of investigations into functional and molecular roles of TRIM25 and other E3 ubiquitin ligases in cell biology and control of pathogenic infections. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition.

中文翻译：

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TRIM25 及其在抗病毒防御中的新兴 RNA 结合作用。

先天免疫系统是人体抵御病毒的第一道防线，其模式识别受体 (PRR) 可识别病毒特有的分子并触发干扰素和其他抗病毒细胞因子的表达，从而形成抗病毒状态。包含 25 (TRIM25) 的三联基序是一种 E3 泛素连接酶，被认为是 PRR 视黄酸诱导基因 I 蛋白 (RIG-I) 信号激活的关键组成部分。TRIM25 最近被确定为一种 RNA 结合蛋白，引发了一个问题，即其 RNA 结合活性是否对其在先天免疫中的作用很重要。在这里，我们回顾了 TRIM25 在未感染和感染细胞中的机制和途径。我们还介绍了解释 TRIM25 与 RNA 结合如何调节其功能并参与抗病毒反应的模型。这些发现开启了对 TRIM25 和其他 E3 泛素连接酶在细胞生物学和病原体感染控制中的功能和分子作用的新研究。本文分类如下：疾病和发展中的 RNA > 疾病中的 RNA RNA 与蛋白质和其他分子的相互作用 > 蛋白质-RNA 相互作用：功能意义 RNA 与蛋白质和其他分子的相互作用 > 蛋白质-RNA 识别。