BACKGROUND Although the presence of seizures in dogs with meningoencephalitis of unknown origin (MUO) has been associated with shorter survival times, data regarding the prevalence and risk factors for postencephalitic epilepsy (PEE) is lacking. OBJECTIVES To describe the clinical features, prevalence, risk factors, and long-term outcome of PEE in dogs with MUO. ANIMALS Sixty-one dogs with presumptive diagnosis of MUO based on the clinicopathological and diagnostic imaging findings. METHODS Retrospective study. Cases were identified by search of hospital medical records for dogs with suspected or confirmed MUO. Medical records of dogs meeting inclusion criteria were reviewed. Signalment, seizure history, clinicopathologic, and magnetic resonance imaging (MRI) findings were recorded. RESULTS Among 61 dogs at risk of PEE, 14 (23%) dogs developed PEE. Three of 14 dogs with PEE (21%) developed drug-resistant epilepsy. Dogs with PEE were younger (P = .03; ORadjusted = 0.75; 95% confidence interval [CI], 0.58-0.98) and had significantly shorter survival times (log-rank test P = .04) when compared to dogs that did not develop epilepsy. The risk factors associated with the development of PEE were the presence of acute symptomatic seizures (ASS; P = .04; ORadjusted = 4.76; 95% CI, 1.11-20.4) and MRI lesions in the hippocampus (P = .04; ORadjusted = 4.75; 95% CI, 1.07-21.0). CONCLUSIONS AND CLINICAL IMPORTANCE Dogs with MUO and seizures at the early stage of the disease (ASS) seem to be at a higher risk of developing PEE.

中文翻译：

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脑源性不明脑膜炎犬的脑病后癫痫：临床特征，危险因素和长期预后。

背景技术尽管在患有未知来源的脑膜脑炎（MUO）的狗中癫痫发作的存在与较短的存活时间有关，但是缺乏关于脑后癫痫（PEE）的患病率和危险因素的数据。目的描述MUO犬的PEE的临床特征，患病率，危险因素和长期预后。动物根据临床病理和诊断影像学发现，对MUO进行推定诊断的61只狗。方法回顾性研究。通过搜索医院病历中疑似或确诊为MUO的狗来确定病例。审查符合入选标准的狗的病历。记录信号，癫痫病史，临床病理和磁共振成像（MRI）结果。结果在61只患PEE风险的狗中，14只（23％）狗患了PEE。14只PEE犬中有3只（21％）出现了耐药性癫痫病。与没有PEE的狗相比，PEE的狗年轻（P = .03； OR调整后= 0.75； 95％置信区间[CI]，0.58-0.98），并且存活时间明显缩短（对数秩检验P = .04）。发展癫痫病。与PEE发生相关的危险因素是急性症状性癫痫发作（ASS; P = .04; OR调整后= 4.76; 95％CI，1.11-20.4）和海马MRI病变（P = .04; OR调整后= 4.75； 95％CI，1.07-21.0）。结论和临床意义患有MUO并在疾病早期（ASS）发作的狗似乎患上PEE的风险更高。与没有发生癫痫的狗相比，该模型具有95％的置信区间[CI]为0.58-0.98），并且存活时间明显缩短（对数秩检验P = .04）。与PEE发生相关的危险因素是急性症状性癫痫发作（ASS; P = .04; OR调整后= 4.76; 95％CI，1.11-20.4）和海马MRI病变（P = .04; OR调整后= 4.75； 95％CI，1.07-21.0）。结论和临床意义患有MUO并在疾病早期（ASS）发作的狗似乎患上PEE的风险更高。与没有发生癫痫的狗相比，该模型具有95％的置信区间[CI]为0.58-0.98），并且存活时间明显缩短（对数秩检验P = .04）。与PEE发生相关的危险因素是急性症状性癫痫发作（ASS; P = .04; OR调整后= 4.76; 95％CI，1.11-20.4）和海马MRI病变（P = .04; OR调整后= 4.75； 95％CI，1.07-21.0）。结论和临床意义患有MUO且在疾病早期（ASS）发作的狗似乎患PEE的风险更高。4）和海马MRI病变（P = .04； OR调整后= 4.75； 95％CI，1.07-21.0）。结论和临床意义患有MUO且在疾病早期（ASS）发作的狗似乎患PEE的风险更高。4）和海马MRI病变（P = .04； OR调整后= 4.75； 95％CI，1.07-21.0）。结论和临床意义患有MUO并在疾病早期（ASS）发作的狗似乎患上PEE的风险更高。