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Monocyclic Peptides: Types, Synthesis and applications.
Current Pharmaceutical Biotechnology ( IF 2.8 ) Pub Date : 2020-12-31 , DOI: 10.2174/1573412916666200120155104
Yalda Khazaei-Poul 1 , Shohreh Farhadi 1 , Sepideh Ghani 1 , Safar Ali Ahmadizad 1 , Javad Ranjbari 2
Affiliation  

Peptides are considered to be appropriate tools in various biological fields. They can be primarily used for the rational design of bioactive molecules. They can act as ligands in the development of targeted therapeutics as well as diagnostics, can be used in the design of vaccines or can be employed in agriculture. Peptides can be classified in two broad structural classes: linear and cyclic peptides. Monocyclic peptides are a class of polypeptides with one macrocyclic ring that bears advantages, such as more selective binding and uptake by the target receptor, as well as higher potency and stability compared to linear types. This paper provides an overview of the categories, synthesis methods and various applications of cyclic peptides. The various applications of cyclic peptides include their use as pro-apoptotic and anti-microbial agents, their application as targeting ligands in drug delivery and diagnostic agents, as well as agricultural and therapeutics applications that are elaborated and discussed in this paper.



中文翻译:

单环肽:类型,合成和应用。

肽被认为是各种生物学领域的合适工具。它们可主要用于合理设计生物活性分子。它们可以在靶向治疗剂和诊断剂的开发中充当配体,可以用于疫苗的设计或可以用于农业。肽可分为两大类:线性和环状肽。单环肽是具有一个大环的一类多肽,其具有优点,例如与线性类型相比,靶标受体具有更高的选择性结合和摄取,以及更高的效能和稳定性。本文概述了环肽的种类,合成方法和各种应用。环肽的各种应用包括用作促凋亡剂和抗微生物剂,

更新日期:2020-12-31
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