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Importance of Stem Cell Migration and Angiogenesis Study for Regenerative Cell-based Therapy: A Review.
Current Stem Cell Research & Therapy ( IF 2.1 ) Pub Date : 2020-03-31 , DOI: 10.2174/1574888x15666200127145923
Nur S Aziz 1 , Norhayati Yusop 2 , Azlina Ahmad 2
Affiliation  

Stem cells play an essential role in maintaining homeostasis, as well as participating in new tissue regeneration. Over the past 20 years, a great deal of effort has been made to investigate the behaviour of stem cells to enable their potential use in regenerative medicine. However, a variety of biological characteristics are known to exist among the different types of stem cells due to variations in the methodological approach, formulation of cell culture medium, isolation protocol and cellular niches, as well as species variation. In recent years, cell-based therapy has emerged as one of the advanced techniques applied in both medical and clinical settings. Cell therapies aim to treat and repair the injury sites and replace the loss of tissues by stimulating the repair and regeneration process. In order to enable the use of stem cells in regenerative therapies, further characterisation of cell behaviour, in terms of their proliferation and differentiation capacity, mainly during the quiescent and inductive state is regarded as highly necessary. The central focus of regenerative medicine revolves around the use of human cells, including adult stem cells and induced pluripotent stem cells for cell-based therapy. The purpose of this review was to examine the existing body of literature on stem cell research conducted on cellular angiogenesis and migration, to investigate the validity of different strategies and variations of the cell type used. The information gathered within this review may then be shared with fellow researchers to assist in future research work, engaging in stem cell homing for cell-based therapy to enhance wound healing and tissue regeneration process.



中文翻译:

干细胞迁移和血管生成研究对基于再生细胞的疗法的重要性:综述。

干细胞在维持体内平衡以及参与新组织再生中起着至关重要的作用。在过去的20年中,人们为研究干细胞的行为付出了巨大的努力,以使其能够在再生医学中得到潜在的应用。然而,由于方法的变化,细胞培养基的配制,分离方案和细胞壁ches以及物种的变化,不同类型的干细胞之间存在着多种生物学特性。近年来,基于细胞的治疗已成为医学和临床应用中应用的先进技术之一。细胞疗法旨在通过刺激修复和再生过程来治疗和修复损伤部位,并弥补组织的损失。为了使干细胞能够用于再生疗法中,就其主要在静止和诱导状态下的增殖和分化能力而言,进一步表征细胞行为是非常必要的。再生医学的主要焦点围绕人类细胞的使用,包括成人干细胞和诱导性多能干细胞进行基于细胞的治疗。这篇综述的目的是研究关于细胞血管生成和迁移的干细胞研究的现有文献,以研究不同策略和所用细胞类型变异的有效性。然后,可以与其他研究人员共享此评论中收集的信息,以协助将来的研究工作,

更新日期:2020-03-31
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