Regenerative medicine represents an emerging multidisciplinary field that brings together engineering methods and complexity of life sciences into a unified fundamental understanding of structure-property relationship in micro/nano environment to develop the next generation of scaffolds and hydrogels to restore or improve tissue functions. Chitosan has several unique physico-chemical properties that make it a highly desirable polysaccharide for various applications such as, biomedical, food, nutraceutical, agriculture, packaging, coating, etc. However, the utilization of chitosan in regenerative medicine is often limited due to its inadequate mechanical, barrier and thermal properties. Cellulosic nanomaterials (CNs), owing to their exceptional mechanical strength, ease of chemical modification, biocompatibility and favorable interaction with chitosan, represent an attractive candidate for the fabrication of chitosan/ CNs scaffolds and hydrogels. The unique mechanical and biological properties of the chitosan/CNs bio-nanocomposite make them a material of choice for the development of next generation bio-scaffolds and hydrogels for regenerative medicine applications. In this review, we have summarized the preparation method, mechanical properties, morphology, cytotoxicity/ biocompatibility of chitosan/CNs nanocomposites for regenerative medicine applications, which comprises tissue engineering and wound dressing applications.

再生医学代表了一个新兴的多学科领域，它将工程学方法和生命科学的复杂性结合到对微观/纳米环境中的结构-性质关系的统一基础理解中，以开发下一代支架和水凝胶以恢复或改善组织功能。壳聚糖具有多种独特的理化性质，使其成为各种应用（如生物医学，食品，营养食品，农业，包装，包衣等）的高度理想的多糖。但是，壳聚糖在再生医学中的应用通常受到限制，因为机械，阻挡层和热性能不足。纤维素纳米材料（CNs）由于其出色的机械强度，易于化学修饰，生物相容性和与壳聚糖的良好相互作用代表了壳聚糖/ CNs支架和水凝胶的制备的有吸引力的候选者。壳聚糖/ CNs生物纳米复合材料的独特机械和生物学特性使其成为开发新一代可再生医学应用生物支架和水凝胶的首选材料。在这篇综述中，我们总结了用于再生医学的壳聚糖/ CNs纳米复合材料的制备方法，力学性能，形态，细胞毒性/生物相容性，包括组织工程和伤口敷料应用。壳聚糖/ CNs生物纳米复合材料的独特机械和生物学特性使其成为开发新一代可再生医学应用生物支架和水凝胶的首选材料。在这篇综述中，我们总结了用于再生医学的壳聚糖/ CNs纳米复合材料的制备方法，力学性能，形态，细胞毒性/生物相容性，包括组织工程和伤口敷料应用。壳聚糖/ CNs生物纳米复合材料的独特机械和生物学特性使其成为开发新一代可再生医学应用生物支架和水凝胶的首选材料。在这篇综述中，我们总结了用于再生医学的壳聚糖/ CNs纳米复合材料的制备方法，力学性能，形态，细胞毒性/生物相容性，包括组织工程和伤口敷料应用。