It is my great pleasure and honor to introduce this special issue of Nucleosides, Nucleotides & Nucleic Acids in celebration of the 70th birthday (KOKI, Japanese traditional celebration of long life at the 70 years old) of Professor Akira Matusda, Emeritus Professor of Hokkaido University. Professor Akira Matusda was born in 1949 in Hokkaido, Japan. After graduating from Hokkaido Sapporo Minami High School, he entered Hokkaido University and obtained his BS form the Faculty of Pharmaceutical Sciences in 1972. In 1977, he was awared his PhD from Hokkaido University, under the direction of late Professor Tohru Ueda. After working as an assistant professor at Hokkaido University for one year, he then worked as a postdoctoral fellow in the research group of Prof. Daniel V. Santi at Unversity of California, San Francisco (1978–1979) and the research group of Drs. Jack J. Fox and Kyoichi A. Watanabe at Memorial Sloan-Kettering Cancer Center (1979–982). He returned to Japan and began again his academic career as an assistant professor at Showa University. In 1985, he came back his alma mater (Faculty of Pharmaceutical Sciences, Hokkaoido University) as an assistant professor. After being an associate professor (1986–1991), he was promoted to professor at Hokkaido University in 1991. During his academic carrer, I studied in his group as an undergraduate and graduate student (1986–1988) and worked with him as a faculty member (1988–2009). As you know, his research background is consistently medicinal chemistry based on nucleosides, nucleotides and nucleic acids. Thus far, five nucleoside derivatives (2-octynyladenosine (2-OA), 2’-deoxy-2’-methylidenecytidine (DMDC), 2’-cyano-2’-deoxy-1-b-D-arabinofuranosylcytosine (CNDAC) and its N-4 palmitoyl derivative (PCNDAC), and 3’-ethynylcytidine (ECyd)) developed by his group have entered clinical trials, and CNDAC is now in phase III clinical trial against acute myeloid leukemia in

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纪念 Akira Matsuda 教授 70 岁生日的核苷、核苷酸和核酸期刊序言

我非常高兴和荣幸地介绍本期特刊《核苷、核苷酸和核酸》，以庆祝北海道大学名誉教授 Akira Matusda 教授 70 岁生日（KOKI，日本传统庆祝长寿的 70 岁） . Akira Matusda 教授于 1949 年出生于日本北海道。从北海道札幌南高中毕业后，他进入北海道大学，并于 1972 年获得了药学部的学士学位。1977 年，他在已故的上田彻教授的指导下获得了北海道大学的博士学位。在北海道大学担任助理教授一年后，他在加州大学丹尼尔·桑蒂教授的研究小组担任博士后研究员，旧金山（1978-1979）和博士研究小组。Jack J. Fox 和 Kyoichi A. Watanabe 在纪念斯隆-凯特琳癌症中心 (1979-982)。他回到日本，再次开始他的学术生涯，担任昭和大学的助理教授。1985年回到母校（北海道大学药学部）担任助理教授。副教授（1986-1991）后，1991年升任北海道大学教授。在他的学术生涯中，我在他的小组学习，作为本科生和研究生（1986-1988），并在他的指导下工作成员（1988-2009）。如您所知，他的研究背景始终是基于核苷、核苷酸和核酸的药物化学。迄今为止，五种核苷衍生物（2-辛基腺苷（2-OA）、