PURPOSE To determine (i) whether intra-articular gadolinium from MR arthrography (MRA) results in gadolinium deposition in the brain and (ii) whether there is a correlation between intra-articular gadolinium dose and intracranial gadolinium deposition. MATERIALS AND METHODS This retrospective study was institutional review board (IRB) approved and HIPAA compliant. The study group included consecutive adult patients who had undergone MRA of the hip or shoulder and subsequent MRI of the brain. None of the patients had a history of intravenous gadolinium exposure. A control group of patients of similar age and sex who were never exposed to gadolinium and had brain MRIs available was included. Signal intensities (SI) of four brain regions: pons, dentate nuclei (DN), globus pallidi (GP), and thalamus (Thal) normalized to cerebrospinal fluid (CSF) and expressed in SI ratios were measured on T1-weighted non-contrast MR images. Groups were compared using the student's t test. Linear correlation analysis of gadolinium dose and brain SI ratios was performed, and Pearson correlation coefficients (r) are reported. RESULTS We identified 109 patients (mean age 44 ± 14 years, 54% men) who had undergone MRA and 149 controls of similar age and sex distribution. There was no significant difference in mean SI ratios of the brain regions between patients and controls: pons/CSF (p = 0.7), DN/CSF (p = 0.4), GP/CSF (p > 0.99), Thal/CSF (p = 0.3). Within the MRA group, gadolinium dose was not associated with SI ratios (p > 0.2). CONCLUSION Our study found no MR evidence of intracranial gadolinium deposition following MRA. In addition, there was no association between intra-articular gadolinium dose and SI ratios in commonly affected regions of the brain.

中文翻译：

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MR关节造影会引起颅内g沉积吗？

目的确定（i）来自MR关节造影（MRA）的关节内intra是否导致脑中g沉积，以及（ii）关节内dose剂量与颅内g沉积之间是否存在相关性。材料与方法这项回顾性研究获得了机构审查委员会（IRB）的认可并符合HIPAA。研究组包括接受过髋部或肩部MRA以及随后的脑部MRI检查的连续成年患者。没有患者有静脉注射g的病史。对照组包括年龄和性别相似的，从未接触过and并且可以进行脑部MRI检查的患者。四个大脑区域的信号强度（SI）：脑桥，齿状核（DN），苍白球（GP），在T1加权的非对比MR图像上测量标准化为脑脊液（CSF）并以SI比表示的丘脑（Thal）。使用学生的t检验比较各组。进行了dose剂量与脑SI比率的线性相关分析，并报告了Pearson相关系数（r）。结果我们确定了109例接受过MRA治疗的患者（平均年龄44±14岁，男性占54％）和149名年龄和性别分布相似的对照组。患者和对照组之间的大脑区域平均SI比没有显着差异：pons / CSF（p = 0.7），DN / CSF（p = 0.4），GP / CSF（p> 0.99），Thal / CSF（p = 0.3）。在MRA组中，g剂量与SI比无关（p> 0.2）。结论我们的研究未发现MRA后颅内ado沉积的MR证据。此外，