This study aimed to evaluate the anxiety, depression and quality of life scores of children and adolescents diagnosed with familial Mediterranean fever (FMF) and compare these scores with the ones of healthy controls. The study group comprised of 130 children and adolescents diagnosed with FMF with a mean age of 12.6 ± 2.58 and control group comprised of 121 healthy controls with a mean age of 11.8 ± 2.84. Both groups were evaluated with child depression inventory (CDI), screen for child anxiety related emotional disorders (SCARED), pediatric quality of life inventory TM 4.0 (PedsQL™ 4.0) questionnaires. The severity of FMF was assessed by Pras scoring system as mild, moderate and severe disease. The comparisons of these three subgroups of FMF were made in terms of anxiety, depression and quality of life. Children and adolescents with FMF had significantly higher median scores of anxiety than healthy controls. The median scores of depression and quality of life were similar between both groups. Patients with a depression score of 19 or above had significantly higher scores of anxiety and longer duration of disease than the patients with a depression score below 19. While the patients with a severe course of FMF had higher median scores of depression and anxiety, they had significantly lower median scores of quality of life. According to our evaluation, patients with FMF had higher anxiety scores and as the disease become severe, not only anxiety scores but also features of depression become overt. An early apprehension of the mood changes of these patients may have a positive influence in the management of FMF. So, a close collaboration between child and adolescent psychiatrist and pediatric rheumatologist is essential for all over well-being of children and adolescents with FMF.

中文翻译：

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评估家族性地中海热儿童和青少年的焦虑，抑郁和生活质量得分。

这项研究旨在评估诊断为家族性地中海热（FMF）的儿童和青少年的焦虑，抑郁和生活质量得分，并将这些得分与健康对照者的得分进行比较。研究组由130名被诊断为FMF的儿童和青少年组成，平均年龄为12.6±2.58，对照组由121名健康对照组组成，平均年龄为11.8±2.84。两组均通过儿童抑郁量表（CDI），儿童焦虑相关情绪障碍筛查（SCARED），儿童生活质量量表TM 4.0（PedsQL™4.0）问卷进行评估。FMF的严重程度通过Pras评分系统评估为轻度，中度和重度疾病。根据焦虑，抑郁和生活质量对这三个FMF亚组进行了比较。FMF儿童和青少年的焦虑中位数得分明显高于健康对照者。两组的抑郁和生活质量中位数得分相似。抑郁得分为19或更高的患者比抑郁得分低于19的患者具有更高的焦虑评分和更长的疾病持续时间。FMF病程较重的患者抑郁和焦虑的中位数得分更高，大大降低了生活质量的中位数。根据我们的评估，FMF患者的焦虑评分较高，并且随着疾病的恶化，不仅焦虑评分而且抑郁症的特征也变得明显。早期了解这些患者的情绪变化可能对FMF的管理产生积极影响。所以，