The Curated Protein Aggregation Database (CPAD) is a manually curated and open-access database dedicated to providing comprehensive information related to mechanistic, kinetic and structural aspects of protein and peptide aggregation. The database has been updated to CPAD 2.0 by significantly expanding datasets and improving the user-interface. Key features of CPAD 2.0 are (i) 83,098 data points on aggregation kinetics experiments, (ii) 565 structures related to aggregation, which are classified into proteins, fibrils, and protein-ligand complexes, (iii) 2031 aggregating/non-aggregating peptides with pre-calculated aggregation properties, and (iv) 912 aggregation-prone regions in amyloidogenic proteins. This database will help the scientific community (a) by facilitating research leading to improved understanding of protein aggregation, (b) by helping develop, validate and benchmark mechanistic and kinetic models of protein aggregation, and (c) by assisting experimentalists with design of their investigations and dissemination of data generated by their studies. CPAD 2.0 can be accessed at https://web.iitm.ac.in/bioinfo2/cpad2/index.html.

策划的蛋白质聚集数据库（CPAD）是一个手动管理的开放式数据库，致力于提供与蛋白质和肽聚集的机械，动力学和结构方面有关的全面信息。通过显着扩展数据集和改进用户界面，数据库已更新为CPAD 2.0。CPAD 2.0的主要特征是（i）聚集动力学实验中的83,098个数据点，（ii）与聚集相关的565个结构，分为蛋白质，原纤维和蛋白质-配体复合物，（iii）2031聚集/非聚集肽具有预先计算的聚集特性，以及（iv）淀粉样蛋白中的912个易于聚集的区域。该数据库将通过促进研究以增进对蛋白质聚集的理解，从而帮助科学界（a）（b）通过帮助开发，验证和基准化蛋白质聚集的力学模型和动力学模型，以及（c）协助实验人员设计调查设计并传播其研究产生的数据。可以通过https://web.iitm.ac.in/bioinfo2/cpad2/index.html访问CPAD 2.0。