Androgen deprivation therapy in combination with definitive radiation therapy is a standard of care for both intermediate-/high-risk localized prostate, locally advanced prostate cancer. Newer hormonal therapies have shown promising results in patients with castration-resistant disease and are now being investigated in early stages, in combination with radiation therapy. In this section, we review the body of evidence elucidating the mechanism of synergy and immune modulation effect of androgen deprivation therapy and radiation therapy, summarize the pivotal studies supporting its use in the nonmetastatic setting, and present the ongoing studies who will likely shape the management of locally advanced disease, in the upcoming years.

中文翻译：

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下一代雄激素剥夺疗法与放疗相结合，用于N0 M0前列腺癌。

雄激素剥夺疗法与确定性放射疗法相结合是中/高危局限性前列腺癌，局部晚期前列腺癌的护理标准。较新的激素疗法在去势抵抗性疾病的患者中显示出令人鼓舞的结果，目前正在与放射疗法结合进行早期研究。在本节中，我们回顾了阐明雄激素剥夺疗法和放射疗法协同作用和免疫调节作用机理的证据，总结了支持其在非转移性环境中使用的关键研究，并提出了可能对治疗产生影响的正在进行的研究在未来几年内会出现局部晚期疾病。