Background: The soluble form of the erythropoietin (Epo) receptor (sEpoR) is an endogenous antagonist of Epo. Decreasing plasma sEpoR increases free Epo, thereby increasing the availability of the hormone. In humans, short-term intermittent normobaric hypoxia exposure reduces sEpoR concentration in plasma. However, whether similar changes occur during continuous hypoxia, such as during high-altitude exposure with ongoing acclimatization, is yet unknown. Therefore, this study aimed to characterize the time-course concentration profile of sEpoR, and also of Epo, reticulocyte count (RC), and hematocrit in healthy lowlanders during 4 days at high altitude.

中文翻译：

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高海拔缺氧会降低Lowlanders的血浆促红细胞生成素可溶性受体浓度。

背景：促红细胞生成素（Epo）受体（sEpoR）的可溶形式是Epo的内源性拮抗剂。降低血浆sEpoR会增加游离Epo，从而增加激素的利用率。在人类中，短期间歇性常压低氧暴露会降低血浆中的sEpoR浓度。然而，尚不清楚在连续的缺氧期间是否发生类似的变化，例如在持续适应环境的高海拔暴露期间。因此，本研究旨在表征健康低地人在高海拔地区4天中sEpoR以及Epo的时程浓度分布，网织红细胞计数（RC）和血细胞比容。