Early treatment of schizophrenia improves outcomes. Clozapine appears to have unique benefit when other antipsychotic medication has failed. This systematic review and meta‐analysis aims to assess clozapine’s superiority over alternative antipsychotic medication and examine whether earlier use is associated with additional benefit.

中文翻译：

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年龄对氯氮平治疗精神分裂症相对疗效的影响

精神分裂症的早期治疗可改善结果。当其他抗精神病药物失败时，氯氮平似乎具有独特的益处。本系统评价和荟萃分析旨在评估氯氮平相对于替代抗精神病药物的优势，并检查早期使用是否与额外的益处相关。