Background: Natural products have been received attention due to their importance in human life as those are biologically active. In this review, there are some reports through different methods related to the synthesis of the indolizidine 195B which was extracted from poisonous frog; however, due to respect nature, the synthesis of natural compounds such as indolizidine has been attracted much attention among scientists and researchers.

Objective: This review discloses the procedures and methods to provide indolizidine 195B from 1989 to 2018 due to their importance as a natural product.

Conclusion: There are several methods to give rise to the indolizidine 195B as a natural product that is highly active from the biological perspective in pharmaceutical chemistry. In summary, many protocols for the preparations of indolizidine 195B from various substrates, several reagents, and conditions have been reported from different aromatic and aliphatic.

背景：由于天然产物具有生物活性，因此它们在人类生活中的重要性已受到关注。在这篇综述中，有一些通过不同方法的报道涉及从有毒青蛙中提取的吲哚并立定195B的合成。然而，由于尊重自然，天然化合物如吲哚并立定的合成已经引起了科学家和研究人员的广泛关注。

目的：由于其作为天然产物的重要性，本综述公开了从1989年至2018年提供吲哚利西定195B的程序和方法。

结论：有多种方法可产生作为天然产物的吲哚并立定195B，从药物化学的生物学角度出发，它具有很高的活性。总之，从不同的底物，几种试剂和条件制备吲哚并啶195B的许多方案已由不同的芳族和脂族报道。