PURPOSE To investigate whether sarcopenia and myosteatosis correlate with the degree of hypertrophy (DH) and kinetic growth rate (KiGR) of the future liver remnant (FLR) in patients with colorectal liver metastases undergoing portal vein embolization (PVE) in preparation for right hepatectomy. MATERIALS AND METHODS Forty-two patients were included. Total liver volume and FLR volume were measured before and 2-4 weeks after PVE. KiGR of the FLR was calculated. Sarcopenia was assessed using the total psoas muscle volume (PMV), the psoas muscle cross-sectional area (PMCS) and the total skeletal muscle index (L3SMI) at the level of 3rd lumbar vertebra. Degree of myosteatosis was assessed by mean muscle attenuation at L3 (L3MA). Correlations between muscle indices and DH and KiGR were assessed using simple linear regression analyses. RESULTS Mean DH was 8.9 ± 5.7%, and mean KiGR was 3.6 ± 2.3. Mean PMV was 55.56 ± 14.19 cm3/m3, mean PMCS was 8.76 ± 2.3 cm2/m2, mean L3SMI was 45.6 ± 9.89 cm2/m2, and mean L3MA was 27.9 ± 18.6 HU. There was a strong positive correlation between PMV and DH (R = 0.503, p = 0.001) and PMV and KiGR (R = 0.545, p < 0.001). Furthermore, there was a moderate correlation between PMCS and KiGR (R = 0.389, p = 0.014). L3SMI and L3MA were neither associated with DH (p = 0.390 and p = 0.768, respectively) nor with KiGR (p = 0.188 and p = 0.929, respectively). CONCLUSION We identified a positive correlation between PMV and PMCS, as markers for sarcopenia, and the KiGR of the FLR after PVE. PMV and PMCS might therefore aid to identify patients who are poor candidates for FLR augmentation using PVE alone.

中文翻译：

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结直肠肝转移患者门静脉栓塞术后肌肉减少症与未来肝脏残余生长率的相关性。


目的 探讨结直肠肝转移瘤患者接受门静脉栓塞术 (PVE) 准备右肝切除术时，肌肉减少症和肌脂肪变性是否与未来肝残余 (FLR) 的肥大程度 (DH) 和动态生长率 (KiGR) 相关。材料和方法 包括 42 名患者。在 PVE 之前和之后 2-4 周测量总肝体积和 FLR 体积。计算FLR的KiGR。使用总腰肌体积 (PMV)、腰肌横截面积 (PMCS) 和第三腰椎水平的总骨骼肌指数 (L3SMI) 评估肌少症。通过 L3 平均肌肉衰减 (L3MA) 评估肌脂肪变性的程度。使用简单线性回归分析评估肌肉指数与 DH 和 KiGR 之间的相关性。结果 平均 DH 为 8.9 ± 5.7%，平均 KiGR 为 3.6 ± 2.3。平均 PMV 为 55.56 ± 14.19 cm3/m3，平均 PMCS 为 8.76 ± 2.3 cm2/m2，平均 L3SMI 为 45.6 ± 9.89 cm2/m2，平均 L3MA 为 27.9 ± 18.6 HU。 PMV 和 DH（R = 0.503，p = 0.001）以及 PMV 和 KiGR（R = 0.545，p < 0.001）之间存在很强的正相关性。此外，PMCS 和 KiGR 之间存在中等相关性（R = 0.389，p = 0.014）。 L3SMI 和 L3MA 既不与 DH 相关（分别为 p = 0.390 和 p = 0.768），也不与 KiGR 相关（分别为 p = 0.188 和 p = 0.929）。结论 我们发现 PMV 和 PMCS（作为肌肉减少症的标志物）与 PVE 后 FLR 的 KiGR 之间呈正相关。因此，PMV 和 PMCS 可能有助于识别不适合单独使用 PVE 进行 FLR 增强的患者。