Diabetes has emerged as a major co-morbidity in cystic fibrosis (CF). The 75 g oral glucose tolerance test (OGTT) is used to screen for CF-related diabetes (CFRD) but is inconvenient, and adherence to screening is poor. The 50 g glucose challenge test (GCT) is shorter, performed non-fasting, and may serve to pre-screen the subset of individuals requiring confirmatory OGTT. We performed a pilot study in twenty-seven CF individuals across the glucose tolerance spectrum to test whether the GCT could identify subjects with abnormal glucose tolerance defined as 2-h OGTT glucose ≥7.8 mmol/L (2 h-AGT) or 1-h defined as 1-hr OGTT glucose ≥11.1 mmol/L (1 h-AGT). A GCT threshold of 8.1 mmol/L was 73% sensitive and 63% specific for 2hr-AGT and 80% sensitive and 65% specific for 1hr-AGT. Therefore, a screening GCT may reduce need for confirmatory OGTT for identifying AGT but a larger study is warranted to identify a robust cutoff for CFRD.

中文翻译：

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囊性纤维化中的异常葡萄糖耐量和 50 克葡萄糖激发试验

糖尿病已成为囊性纤维化 (CF) 的主要合并症。75g口服葡萄糖耐量试验（OGTT）用于筛查CF相关糖尿病（CFRD），但不方便，筛查依从性差。50 g 葡萄糖激发试验 (GCT) 较短，非空腹进行，可用于预筛选需要确认性 OGTT 的个体子集。我们在葡萄糖耐量范围内的 27 名 CF 个体中进行了一项初步研究，以测试 GCT 是否可以识别定义为 2 小时 OGTT 葡萄糖≥7.8 mmol/L (2 h-AGT) 或 1 小时的异常葡萄糖耐量的受试者定义为 1 小时 OGTT 葡萄糖≥11.1 mmol/L (1 h-AGT)。8.1 mmol/L 的 GCT 阈值对 2hr-AGT 的敏感性为 73%，特异性为 63%，对 1hr-AGT 的敏感性为 80%，特异性为 65%。所以，