Background: 

Nonarteritic anterior ischemic optic neuropathy (NA-AION) associated with optic disc drusen (ODD) is termed ODD-AION, where NA-AION with no evidence of ODD is simply termed NA-AION. Patients with ODD-AION have been found to be younger than those with NA-AION but with similar vascular risk factors. This study compares the known risk factors for NA-AION between a group with ODD-AION and a similarly aged group with NA-AION.

Methods: 

A case–control study of 13 patients with ODD-AION and 14 patients with NA-AION diagnosed in the period 2008–2017. All patients underwent an interview designed to evaluate history of vascular risk factors and comorbidities and re-examination including enhanced depth imaging optical coherence tomography to confirm the presence or absence of ODD.

Results: 

No significant differences were found in demographic or clinical characteristics between the ODD-AION and the NA-AION group. Significantly more ODD-AION patients than NA-AION patients had no vascular risk factors (smoking, arterial hypertension, diabetes mellitus, and dyslipidemia) present (P = 0.047). Significantly fewer patients in the ODD-AION group were diagnosed with arterial hypertension or dyslipidemia than in the NA-AION group.

Conclusions: 

In this cross-sectional study, the ODD-AION patients more often had no vascular risk factors as compared to NA-AION patients, which supports the hypothesis that ODD are an independent risk factor for AION.

中文翻译：

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视盘玻璃膜疣相关的前部缺血性视神经病变：合并症和血管危险因素的患病率。

背景： 

与视盘玻璃膜疣（ODD）相关的非动脉性前部缺血性视神经病变（NA-AION）称为ODD-AION，而没有ODD证据的NA-AION简称为NA-AION。已发现ODD-AION患者比NA-AION患者年轻，但具有相似的血管危险因素。这项研究比较了ODD-AION组和类似年龄的NA-AION组中NA-AION的已知危险因素。

方法： 

在2008-2017年期间对13例ODD-AION患者和14例NA-AION患者进行了病例对照研究。所有患者均接受了旨在评估血管危险因素和合并症历史的访谈，并进行了复查，包括增强深度成像光学相干断层扫描以确认是否存在ODD。

结果： 

在ODD-AION和NA-AION组之间，在人口统计学或临床特征上没有发现显着差异。没有NAD-AION患者的无血管危险因素（吸烟，动脉高压，糖尿病和血脂异常）明显多于NA-AION患者（P = 0.047）。与NA-AION组相比，ODD-AION组被诊断出患有动脉高压或血脂异常的患者少得多。

结论： 

在这项横断面研究中，与NA-AION患者相比，ODD-AION患者更没有血管危险因素，这支持了ODD是AION的独立危险因素的假设。