The fallopian tube is thought to be the site of origin of most high-grade serous carcinomas (HGSCs). However, how often the tube is abnormal in the setting of other ovarian tumors is unknown. The aim of this study is to define the frequency of tubal abnormalities in the tumoral (n = 245) and nontumoral (n = 184) setting. We found that in ovarian tumors, 52.2% of the tubes were normal, while 39.2% were affected by the tumor. Abnormal tubes were found in 80% of HGSCs, in 21% of mucinous carcinomas, in 83.3% of seromucinous carcinomas, in 33.3% of endometrioid carcinomas, in 20% of clear-cell carcinomas, and in 10.5% of borderline tumors. Among normal tubes, almost 70% were histologically normal; transitional metaplasia was present in 17.4%, endometriosis in 8.1%, and adenofibroma in 2.2%, and 1.1% had an incidental serous intraepithelial tubal carcinoma. To conclude, the fallopian tube is abnormal in most serous carcinomas, and in a smaller number of endometrioid, clear-cell and mucinous carcinomas as well as borderline tumors. It is often abnormal in seromucinous tumors, but larger series are needed to study this rare subtype.

中文翻译：

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输卵管病理学：输卵管受卵巢肿瘤和非肿瘤环境中的偶然发现

输卵管被认为是大多数高级别浆液性癌 (HGSC) 的起源部位。然而，在其他卵巢肿瘤的情况下，输卵管异常的频率尚不清楚。本研究的目的是确定肿瘤（n = 245）和非肿瘤（n = 184）环境中输卵管异常的频率。我们发现在卵巢肿瘤中，52.2% 的管子是正常的，而 39.2% 的管子受到肿瘤的影响。在 80% 的 HGSC、21% 的粘液癌、83.3% 的浆液性粘液癌、33.3% 的子宫内膜样癌、20% 的透明细胞癌和 10.5% 的交界性肿瘤中发现异常管。在正常管中，几乎 70% 的组织学正常；17.4% 存在移行性化生，8.1% 存在子宫内膜异位症，2.2% 存在腺纤维瘤，1. 1% 有偶然的浆液性上皮内输卵管癌。总而言之，输卵管在大多数浆液性癌中是异常的，在少数子宫内膜样癌、透明细胞癌和粘液癌以及交界性肿瘤中是异常的。它在血清粘液性肿瘤中通常是异常的，但需要更大的系列来研究这种罕见的亚型。