OBJECTIVE Sexual and gender minority individuals assigned female at birth (SGM-AFAB) are at increased risk for anxiety, depression, and substance use and problems compared with heterosexual cisgender women. Cross-sectional research has demonstrated that minority stressors are associated with anxiety, depression, and substance use. However, longitudinal research is limited and the examination of prospective associations between minority stressors, mental health, and substance use is even more sparse. METHOD We utilized 4 waves of data (6 months between waves) from a diverse (26.0% non-Latinx White; 26.2% gender minorities) longitudinal cohort of 488 SGM-AFAB (16- to 32-years-old at Wave 1) to examine concurrent and prospective associations between 3 minority stressors (internalized stigma, microaggressions, victimization) and anxiety, depression, and alcohol and cannabis use and problems. RESULTS At the within-person level, results indicated that when SGM-AFAB experienced more minority stressors than usual, they reported more concurrent and prospective anxiety and depression. Additionally, when SGM-AFAB experienced more microaggressions than usual, they were more likely to use alcohol and cannabis, and when they experienced more victimization than usual, they reported more concurrent alcohol and cannabis use problems. No prospective associations between minority stressors and substance use were significant. CONCLUSIONS Findings indicate that minority stressors were consistently associated with internalizing symptoms, both concurrently and prospectively, while evidence for associations between minority stressors and substance use/problems was less consistent. These findings highlight the need for interventions that that teach SGM-AFAB skills for effectively coping with minority stress. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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在出生时分配给女性的性别和性别少数群体中，少数群体的压力，内在症状和物质使用之间的纵向关联。

目的与异性恋的顺带女性相比，出生时分配给女性的性别和性别少数群体（SGM-AFAB）患焦虑，抑郁，吸毒和出现问题的风险增加。横断面研究表明，少数压力源与焦虑，抑郁和药物滥用相关。然而，纵向研究是有限的，对少数族裔压力源，心理健康和药物使用之间的前瞻性关联的检查更加稀疏。方法我们使用了488个SGM-AFAB（第1浪年龄为16至32岁）的纵向队列（共​​26.0％的非拉丁裔白人； 26.2％的性别少数群体）中的4浪数据（两次浪涌之间的6个月）检查3个少数族裔应激源（内在的污名，微侵略，受害）与焦虑，抑郁之间的并发和预期关联，以及酒精和大麻的使用和问题。结果在人内方面，结果表明，当SGM-AFAB遭受的少数民族压力比平时更多时，他们报告了更多的并发性和前瞻性焦虑和抑郁。此外，当SGM-AFAB比平常遭受更多的微侵害时，他们更有可能使用酒精和大麻，而当他们遭受比平常更多的伤害时，他们报告了更多的并发酒精和大麻使用问题。少数族裔压力源与物质使用之间没有明显的关联。结论研究结果表明，少数应激源与内在症状同时发生和前瞻性持续相关，而少数应激源与物质使用/问题之间关联的证据则不一致。这些发现凸显了需要采取干预措施来教授SGM-AFAB技能以有效应对少数群体压力的需求。（PsycINFO数据库记录（c）2020 APA，保留所有权利）。