We review the mechanism and consequences of the 'bridging-induced attraction', a generic biophysical principle that underpins some existing models for chromosome organization in 3D. This attraction, which was revealed in polymer physics-inspired computer simulations, is a generic clustering tendency arising in multivalent chromatin-binding proteins, and it provides an explanation for the biogenesis of nuclear bodies and transcription factories via microphase separation. Including post-translational modification reactions involving these multivalent proteins can account for the fast dynamics of the ensuing clusters, as is observed via microscopy and photobleaching experiments. The clusters found in simulations also give rise to chromatin domains that conform well with the observation of A/B compartments in HiC experiments.

中文翻译：

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桥接诱导的微相分离：光漂白实验，染色质域和需要进行活性反应。

我们回顾了“桥接诱导的吸引力”的机制和后果，这是一种通用的生物物理原理，为3D染色体组织的一些现有模型奠定了基础。在高分子物理学启发的计​​算机模拟中揭示了这种吸引力，它是多价染色质结合蛋白中出现的一种普遍的聚集趋势，它为核体和转录工厂通过微相分离的生物发生提供了解释。如通过显微镜和光漂白实验所观察到的那样，包括涉及这些多价蛋白的翻译后修饰反应可以解释随后簇的快速动力学。在模拟中发现的簇也产生了染色质结构域，其与HiC实验中对A / B区室的观察非常吻合。