The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was conducted comparing the prevalence of SLE among patients with AA and among age-, sex-, and ethnicity-matched control subjects. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the computerized database of Clalit Health Services ensuring 4.4 million subjects. A total of 51,561 patients with AA and 51,410 controls were included in the study. The prevalence of SLE was increased in patients with AA as compared to the control group (0.3% vs. 0.1%, respectively; OR, 2.1; 95% CI, 1.6-2.9; P < 0.001). The association increased consistently with age and was stronger among female and Jewish patients. In a multivariate analysis adjusting for sex, age, ethnicity, and other comorbidities, AA was still associated with SLE (OR, 2.1; 95% CI, 1.6-2.9; P < 0.001). To conclude, a significant positive association was observed between AA and SLE. Further longitudinal observational studies are necessary to establish these findings in other study populations. Physicians treating patients with AA may be aware of this possible association and may consider screening for SLE in patients with relevant symptoms.

中文翻译：

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斑秃和系统性红斑狼疮之间有联系吗？基于人群的研究。

已经描述了斑秃（AA）和系统性红斑狼疮（SLE）的共存，但是这些条件之间的关联尚待确定。我们旨在使用大规模的现实生活计算机数据库来评估AA和SLE之间的关联。进行了一项横断面研究，比较了AA患者和年龄，性别和种族匹配的对照对象中SLE的患病率。卡方检验和t检验用于单变量分析，逻辑回归模型用于多变量分析。这项研究是利用Clalit Health Services的计算机数据库进行的，可确保440万名受试者。该研究共纳入51,561名AA患者和51,410名对照。与对照组相比，AA患者的SLE患病率增加（0。分别为3％和0.1％；或2.1; 95％CI，1.6-2.9；P <0.001）。该关联性随着年龄的增长而不断增加，在女性和犹太人患者中则更强。在调整了性别，年龄，种族和其他合并症的多元分析中，AA仍与SLE相关（OR为2.1； 95％CI为1.6-2.9； P <0.001）。总之，在AA和SLE之间观察到显着的正相关。为了在其他研究人群中建立这些发现，有必要进行进一步的纵向观察研究。治疗AA患者的医师可能会意识到这种可能的关联，并可能考虑对具有相关症状的患者进行SLE筛查。在调整了性别，年龄，种族和其他合并症的多因素分析中，AA仍与SLE相关（OR为2.1； 95％CI为1.6-2.9； P <0.001）。总之，在AA和SLE之间观察到显着的正相关。为了在其他研究人群中建立这些发现，有必要进行进一步的纵向观察研究。治疗AA患者的医师可能会意识到这种可能的关联，并可能考虑对具有相关症状的患者进行SLE筛查。在调整了性别，年龄，种族和其他合并症的多元分析中，AA仍与SLE相关（OR为2.1； 95％CI为1.6-2.9； P <0.001）。总之，在AA和SLE之间观察到显着的正相关。为了在其他研究人群中建立这些发现，有必要进行进一步的纵向观察研究。治疗AA患者的医师可能会意识到这种可能的关联，并可能考虑对具有相关症状的患者进行SLE筛查。