Alzheimer’s disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes.

中文翻译：

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斑块相关骨髓细胞源自阿尔茨海默病模型中的常驻小胶质细胞

阿尔茨海默病 (AD) 伴随着由大脑斑块相关骨髓细胞介导的强烈炎症反应。这些细胞表现出改变的基因表达谱并充当屏障，预防神经炎性营养不良。这些细胞的起源一直存在争议，并且具有治疗重要性。在这里，我们对不同的骨髓细胞群体进行了基因标记，并明确证明 AD 大脑中与斑块相关的骨髓细胞完全源自常驻小胶质细胞，而循环外周单核细胞没有贡献。