Objective: We compared the placebo response (PR) as measured by the Test of Variables of Attention (TOVA) and the Conners' Adult ADHD Rating Scale (CAARS) scores. Method: A retrospective data analysis from a double-blind placebo-controlled study of metadoxine-ER in adults with ADHD. An additional database was used for comparison to TOVA response after methylphenidate challenge (TOVA-MPH-R). Results: PR was highest when calculated from the TOVA-Attention Composite Score (ACS). The PR showed significantly fewer variables improving concomitantly compared with MPH-R. The most prominent correlation between the CAARS-PR and the TOVA-PR was in the Omissions score (p = .032), which was age-dependent (b = .0007, p <.001). Discussion: TOVA-PR has an index-specific profile compared with CAARS-PR and TOVA-MPH-R. The partial correlation of TOVA-PR with CAARS-PR suggests that a composite score of TOVA specific indices and CAARS could have a synergic impact to improve the reliability of the response assessment in adult ADHD.

中文翻译：

---

通过 TOVA 连续性能测试客观评估成人 ADHD 的安慰剂反应。

目的：我们比较了通过注意力变量测试 (TOVA) 和康纳斯成人 ADHD 评定量表 (CAARS) 评分测量的安慰剂反应 (PR)。方法：对成人 ADHD 患者进行的美多辛-ER 双盲安慰剂对照研究的回顾性数据分析。另一个数据库用于比较哌醋甲酯攻击后的 TOVA 反应 (TOVA-MPH-R)。结果：从 TOVA 注意力综合评分 (ACS) 计算时，PR 最高。与 MPH-R 相比，PR 显示伴随改善的变量显着减少。CAARS-PR 和 TOVA-PR 之间最显着的相关性在于遗漏评分 (p = .032)，它与年龄有关 (b = .0007, p <.001)。讨论：与 CAARS-PR 和 TOVA-MPH-R 相比，TOVA-PR 具有特定于指数的特征。